دورية أكاديمية
Association of Receiving Multiple, Concurrent Fracture-Associated Drugs With Hip Fracture Risk.
| العنوان: | Association of Receiving Multiple, Concurrent Fracture-Associated Drugs With Hip Fracture Risk. |
|---|---|
| المؤلفون: | Emeny, Rebecca T, Chang, Chiang-Hua, Skinner, Jonathan, O'Malley, A James, Smith, Jeremy, Chakraborti, Gouri, Rosen, Clifford J, Morden, Nancy E |
| المصدر: | Maine Medical Center |
| بيانات النشر: | MaineHealth Knowledge Connection |
| سنة النشر: | 2019 |
| المجموعة: | MaineHealth Knowledge Connection |
| مصطلحات موضوعية: | Hip Fractures, Fractures, Multiple, Pelvic Bones, Musculoskeletal System, Orthopedics |
| الوصف: | Importance: Many prescription drugs increase fracture risk, which raises concern for patients receiving 2 or more such drugs concurrently. Logic suggests that risk will increase with each additional drug, but the risk of taking multiple fracture-associated drugs (FADs) is unknown. Objective: To estimate hip fracture risk associated with concurrent exposure to multiple FADs. Design, Setting, and Participants: This cohort study used a 20% random sample of Medicare fee-for-service administrative data for age-eligible Medicare beneficiaries from 2004 to 2014. Sex-stratified Cox regression models estimated hip fracture risk associated with current receipt of 1, 2, or 3 or more of 21 FADs and, separately, risk associated with each FAD and 2-way FAD combination vs no FADs. Models included sociodemographic characteristics, comorbidities, and use of non-FAD medications. Analyses began in November 2018 and were completed April 2019. Exposure: Receipt of prescription FADs. Main Outcomes and Measures: Hip fracture hospitalization. Results: A total of 11.3 million person-years were observed, reflecting 2 646 255 individuals (mean [SD] age, 77.2 [7.3] years, 1 615 613 [61.1%] women, 2 136 585 [80.7%] white, and 219 579 [8.3%] black). Overall, 2 827 284 person-years (25.1%) involved receipt of 1 FAD; 1 322 296 (11.7%), 2 FADs; and 954 506 (8.5%), 3 or more FADs. In fully adjusted, sex-stratified models, an increase in hip fracture risk among women was associated with the receipt of 1, 2, or 3 or more FADs (1 FAD: hazard ratio [HR], 2.04; 95% CI, 1.99-2.11; P < .001; 2 FADs: HR, 2.86; 95% CI, 2.77-2.95; P < .001; ≥3 FADs: HR, 4.50; 95% CI, 4.36-4.65; P < .001). Relative risks for men were slightly higher (1 FAD: HR, 2.23; 95% CI, 2.11-2.36; P < .001; 2 FADs: HR, 3.40; 95% CI, 3.20-3.61; P < .001; ≥3 FADs: HR, 5.18; 95% CI, 4.87-5.52; P < .001). Among women, 2 individual FADs were associated with HRs greater than 3.00; 80 pairs of FADs exceeded this threshold. Common, risky pairs among women included sedative ... |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://knowledgeconnection.mainehealth.org/mmc/1736Test; https://pubmed.ncbi.nlm.nih.gov/31722031Test |
| الإتاحة: | https://knowledgeconnection.mainehealth.org/mmc/1736Test https://pubmed.ncbi.nlm.nih.gov/31722031Test |
| رقم الانضمام: | edsbas.1BD9926F |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |