دورية أكاديمية
Correlates and outcomes of late and very late drug-eluting stent thrombosis: results from DESERT (International Drug-Eluting Stent Event Registry of Thrombosis).
| العنوان: | Correlates and outcomes of late and very late drug-eluting stent thrombosis: results from DESERT (International Drug-Eluting Stent Event Registry of Thrombosis). |
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| المؤلفون: | Waksman, Ron, Kirtane, Ajay J, Torguson, Rebecca, Cohen, David J, Ryan, Thomas, Räber, Lorenz, Applegate, Robert, Waxman, Sergio, Gordon, Paul, Kaneshige, Kimberly, Leon, Martin B |
| المصدر: | Maine Medical Center |
| بيانات النشر: | MaineHealth Knowledge Connection |
| سنة النشر: | 2014 |
| المجموعة: | MaineHealth Knowledge Connection |
| مصطلحات موضوعية: | Aged, Coronary Angiography, Coronary Artery Disease, Coronary Thrombosis, Drug Therapy, Combination, Drug-Eluting Stents, Female, Hospital Mortality, Humans, Logistic Models, Male, Middle Aged, Multivariate Analysis, Myocardial Infarction, Odds Ratio, Percutaneous Coronary Intervention, Platelet Aggregation Inhibitors, Prosthesis Design, Registries, Retrospective Studies, Risk Assessment, Risk Factors, Time Factors, Treatment Outcome, Cardiology, Cardiovascular Diseases, Surgery |
| الوصف: | OBJECTIVES: The aim of this study was to identify clinical, procedural, and angiographic correlates of late/very late drug-eluting stent (DES) thrombosis as well as to determine the clinical outcomes of these events. BACKGROUND: Late/very late DES thromboses are a poorly studied phenomenon, partly due to the relative infrequency of these events, even in large cohort studies. METHODS: In the DESERT (International Drug-Eluting Stent Event Registry of Thrombosis), a retrospective, case-control registry, 492 cases of late/very late definite DES thrombosis from 21 international sites were matched in a 1:1 fashion with controls without stent thrombosis (ST). Controls were matched according to 2 criteria: same enrolling institution and date of initial DES implantation. Baseline and procedural variables were collected, and clinical follow-up was obtained for patients with ST as long as 1 year after the event. Offline quantitative coronary angiography was performed for a subset of 378 case-control pairs. RESULTS: The majority of ST events occurred after 1 year (75%) and continued to occur for as long as 7.3 years. The clinical presentation of late/very late ST events was mainly myocardial infarction (66.7% ST-segment elevation myocardial infarction and 22.0% non-ST-segment elevation myocardial infarction); in-hospital mortality was 3.8%. A minority of patients (30%) with ST were receiving dual-antiplatelet therapy at the time of the event. Independent clinical correlates of late/very late ST were younger age, African-American race, current smoking, multivessel disease, longer stented length, overlapping stents, and percutaneous coronary intervention of vein graft lesions. Independent angiographic correlates for late/very late ST were lesions within the left anterior descending artery or a bypass graft, thrombus, and a larger residual diameter stenosis after the initial DES implantation. Despite the large sample of ST cases, all identified correlates of late/very late ST had weak associations with subsequent ST (all odds ... |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://knowledgeconnection.mainehealth.org/mmc/136Test; https://www.ncbi.nlm.nih.gov/pubmed/25240540Test/ |
| الإتاحة: | https://knowledgeconnection.mainehealth.org/mmc/136Test https://www.ncbi.nlm.nih.gov/pubmed/25240540Test/ |
| رقم الانضمام: | edsbas.F021BD1 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |