دورية أكاديمية
Reshaping Lipid Biochemistry by Pushing Barriers in Structural Lipidomics
| العنوان: | Reshaping Lipid Biochemistry by Pushing Barriers in Structural Lipidomics |
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| المؤلفون: | Siegel, Tiffany Porta, Ekroos, Kim, Ellis, Shane R. |
| المصدر: | Siegel , T P , Ekroos , K & Ellis , S R 2019 , ' Reshaping Lipid Biochemistry by Pushing Barriers in Structural Lipidomics ' , Angewandte Chemie-International Edition , vol. 58 , no. 20 , pp. 6492-6501 . https://doi.org/10.1002/anie.201812698Test |
| سنة النشر: | 2019 |
| المجموعة: | Maastricht University Research Publications |
| مصطلحات موضوعية: | biochemistry, isomers, lipidomics, mass spectrometry, structural identification, OZONE-INDUCED DISSOCIATION, NM ULTRAVIOLET PHOTODISSOCIATION, MOBILITY-MASS-SPECTROMETRY, DOUBLE-BOND POSITION, ACYL-CHAIN POSITION, ELECTROSPRAY-IONIZATION, LIQUID-CHROMATOGRAPHY, QUANTITATIVE-ANALYSIS, SHOTGUN LIPIDOMICS, MEMBRANE-LIPIDS |
| الوصف: | Lipidomics is a rapidly growing field with numerous examples showing the importance of lipid molecules throughout biology. It has also shed light onto the vast and complex functions performed by many lipids that possess an immense diversity in molecular structures. Mass spectrometry (MS) is the tool of choice for analyzing lipids and has been the key catalyst driving the field forward. However, MS does not yet permit true molecular lipidomics wherein the identification and quantification of lipids having defined molecular structures can be routinely achieved. Here we describe recent advances in MS-based lipidomics that allow access to higher levels of molecular information in lipidomics experiments. These advances will form a key piece of the puzzle as the field moves towards systems characterization of lipids at the molecular level. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/anie.201812698 |
| الإتاحة: | https://doi.org/10.1002/anie.201812698Test https://cris.maastrichtuniversity.nl/en/publications/4823f940-ac90-420f-aa1b-26a3181eb1dfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.51B94784 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/anie.201812698 |
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