دورية أكاديمية
Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy
| العنوان: | Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy |
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| المؤلفون: | Labrador, Jorge, Luno, Elisa, Vellenga, Edo, Brunet, Salut, Gonzalez-Campose, Jose, Chillon, Maria C., Holowiecka, Aleksandra, Esteve, Jordi, Bergua, Juan, Gonzalez-Sanmiguel, Jose D., Gil, Cristina, Tormo, M., Salamero, Olga, Manso, Felix, Fernandez, Isolda, de laSerna, Javier, Moreno, Maria-Jose, Perez-Encinas, M., Krsnik, Isabel, Ribera, Josep-Maria, Cervera, Jose, Calasanz, Maria J., Boluda, Blanca, Sobas, Marta, Lowenberg, Bob, Sanz, Miguel A., Montesinos, Pau, Palmer, L., Fernandez, Ciarlo, S., Bezares, F., Rojas, F., Longoni, H., Gelemur, M., Fazio, P., Canepa, C., Saba, S., Balladares, G., Negri, P., Giunta, M., Milone, J., Prates, M., Lafalse, D., Sossa, C., Jaramillo, F., Mayer, J., Ramos, F., Martinez, J., de Groot, M. R., Schouten, H. C. |
| المصدر: | Labrador , J , Luno , E , Vellenga , E , Brunet , S , Gonzalez-Campose , J , Chillon , M C , Holowiecka , A , Esteve , J , Bergua , J , Gonzalez-Sanmiguel , J D , Gil , C , Tormo , M , Salamero , O , Manso , F , Fernandez , I , de laSerna , J , Moreno , M-J , Perez-Encinas , M , Krsnik , I , Ribera , J-M , Cervera , J , Calasanz , M J , Boluda , B , Sobas , M .... |
| سنة النشر: | 2019 |
| المجموعة: | Maastricht University Research Publications |
| مصطلحات موضوعية: | Acute promyelocytic leukemia, complex karyotype, ATRA, chemotherapy, prognostic, relapse, TRANS-RETINOIC ACID, ADDITIONAL CHROMOSOME-ABNORMALITIES, RISK-ADAPTED TREATMENT, ARSENIC TRIOXIDE, ANTHRACYCLINE MONOCHEMOTHERAPY, PROGNOSTIC-SIGNIFICANCE, CONSOLIDATION THERAPY, CYTOGENETIC CHANGES, FLT3 MUTATIONS, PETHEMA |
| الوصف: | Although additional cytogenetic abnormalities (ACA) do not affect the prognosis of patients with t(15;17) acute promyelocytic leukemia (APL), the role of a complex karyotype (CK) is yet to be clarified. We aimed to investigate the relationship of CK with relapse incidence in 1559 consecutive APL patients enrolled in three consecutive trials. Treatment consisted of AIDA induction followed by risk-adapted consolidation. A CK (CK) was defined as the presence of >= 2 ACA, and a very CK (CK+) as >= 3 ACA. Eighty-nine patients (8%) had a CK, of whom 41 (4%) had CK+. The 5-year cumulative incidence of relapse (CIR) in patients with CK was 18%, and 12% in those with |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1080/10428194.2018.1522438 |
| الإتاحة: | https://doi.org/10.1080/10428194.2018.1522438Test https://cris.maastrichtuniversity.nl/en/publications/d44f681e-b4e9-4ee9-836b-86089a19546fTest |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.461A77AA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1080/10428194.2018.1522438 |
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