دورية أكاديمية
Lymphocyte activation in silica-exposed workers
| العنوان: | Lymphocyte activation in silica-exposed workers |
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| المؤلفون: | Rocha-Parise, Michelle, Santos, Leonilda M. B., Damoiseaux, Jan G. M. C., Bagatin, Ericson, Lido, Alessandro V., Torello, Cristiane Okuda, Cohen Tervaert, Jan W., Queiroz, Mary L. S. |
| المصدر: | Rocha-Parise , M , Santos , L M B , Damoiseaux , J G M C , Bagatin , E , Lido , A V , Torello , C O , Cohen Tervaert , J W & Queiroz , M L S 2014 , ' Lymphocyte activation in silica-exposed workers ' , International Journal of Hygiene and Environmental Health , vol. 217 , no. 4-5 , pp. 586-591 . https://doi.org/10.1016/j.ijheh.2013.11.002Test |
| سنة النشر: | 2014 |
| المجموعة: | Maastricht University Research Publications |
| مصطلحات موضوعية: | Lymphocytes, Soluble IL-2 receptor alpha, Interleukin-2, Silica, Cytokines, Autoimmunity |
| الوصف: | Exposure to silica dust has been examined as a possible risk factor for autoimmune diseases, including systemic sclerosis, rheumatoid arthritis, systemic lupus erythematosus and ANCA-associated vasculitis. However, the underlying cellular and molecular mechanisms resulting in the increased prevalence of autoimmunity remain elusive. To clarify these mechanisms, we studied various markers of immune activation in individuals occupationally exposed to silica dust, i.e., serum levels of soluble IL-2 receptor (sIL-2R), levels of IL-2, other pro- and anti-inflammatory cytokines and lymphoproliferation. Our results demonstrate that silica-exposed individuals present important alterations in their immune response when compared to controls, as shown by increased serum sIL-2R levels, decreased production of IL-2 and increased levels of the pro-inflammatory (IFN-gamma, IL-1 alpha, TNF-alpha, IL-6) as well as anti-inflammatory (IL-10 and TGF-beta) cytokines. Furthermore, silica-exposed individuals presented enhanced lymphoproliferative responses. Our findings provide evidence that the maintenance of immune homeostasis may be disturbed in silica-exposed individuals, possibly resulting in autoimmune disorders. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1016/j.ijheh.2013.11.002 |
| الإتاحة: | https://doi.org/10.1016/j.ijheh.2013.11.002Test https://cris.maastrichtuniversity.nl/en/publications/8959e835-e7cc-4d70-aecb-134e21a3ccf7Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.8D24641E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ijheh.2013.11.002 |
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