دورية أكاديمية
Association of maternal prenatal smoking GFI1-locus and cardiometabolic phenotypes in 18,212 adults
| العنوان: | Association of maternal prenatal smoking GFI1-locus and cardiometabolic phenotypes in 18,212 adults |
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| المؤلفون: | Parmar, Priyanka, Lowry, Estelle, Cugliari, Giovanni, Suderman, Matthew, Wilson, Rory, Karhunen, Ville, Andrew, Toby, Wiklund, Petri, Wielscher, Matthias, Guarrera, Simonetta, Teumer, Alexander, Lehne, Benjamin, Milani, Lili, de Klein, Niek, Mishra, Pashupati P., Melton, Phillip E., Mandaviya, Pooja R., Kasela, Silva, Nano, Jana, Zhang, Weihua, Zhang, Yan, Uitterlinden, Andre G., Peters, Annette, Schoettker, Ben, Gieger, Christian, Anderson, Denise, Boomsma, Dorret, Grabe, Hans J., Panico, Salvatore, Veldink, Jan H., van Meurs, Joyce B. J., van den Berg, Leonard, Beilin, Lawrence J., Franke, Lude, Loh, Marie, van Greevenbroek, Marleen M. J., Nauck, Matthias, Kahonen, Mika, Hurme, Mikko A., Raitakari, Olli T., Franco, Oscar H., Slagboom, P. Eline, van der Harst, Pim, Kunze, Sonja, Felix, Stephan B., Zhang, Tao, Chen, Wei, Mori, Trevor A., Bonnefond, Amelie, Heijmans, Bastiaan T., Jarvelin, Marjo-Riitta, Sebert, Sylvain |
| المصدر: | Parmar , P , Lowry , E , Cugliari , G , Suderman , M , Wilson , R , Karhunen , V , Andrew , T , Wiklund , P , Wielscher , M , Guarrera , S , Teumer , A , Lehne , B , Milani , L , de Klein , N , Mishra , P P , Melton , P E , Mandaviya , P R , Kasela , S , Nano , J , Zhang , W , Zhang , Y , Uitterlinden , A G , Peters , A , Schoettker , .... |
| سنة النشر: | 2018 |
| المجموعة: | Maastricht University Research Publications |
| مصطلحات موضوعية: | EPIGENOME-WIDE ASSOCIATION, DNA METHYLATION, CARDIOVASCULAR-DISEASE, CIGARETTE-SMOKING, BIRTH-WEIGHT, PREGNANCY, CESSATION, EXPOSURE, RISK, DIET |
| الوصف: | Background: DNA methylation at the GFI1-locus has been repeatedly associated with exposure to smoking from the foetal period onwards. We explored whether DNA methylation may be a mechanism that links exposure to maternal prenatal smoking with offspring's adult cardio-metabolic health. Methods: We meta-analysed the association between DNA methylation at GFI1-locus with maternal prenatal smoking, adult own smoking, and cardio-metabolic phenotypes in 22 population-based studies from Europe, Australia, and USA (n= 18,212). DNA methylation at the GFI1-locus was measured in whole-blood. Multivariable regression models were fitted to examine its association with exposure to prenatal and own adult smoking. DNA methylation levels were analysed in relation to body mass index (BMI), waist circumference (WC), fasting glucose (FG), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), diastolic, and systolic blood pressure (BP). Findings: Lower DNA methylation at three out of eight GFI1-CpGs was associated with exposure to maternal prenatal smoking, whereas, all eight CpGs were associated with adult own smoking. Lower DNA methylation at cg14179389, the strongest maternal prenatal smoking locus, was associated with increased WC and BP when adjusted for sex, age, and adult smoking with Bonferroni-corrected P <0.012. In contrast, lower DNA methylation at cg09935388, the strongest adult own smoking locus, was associated with decreased BMI, WC, and BP (adjusted 1 x 10(-7) Interpretation: Epigenetic changes at the GFI1 were linked to smoking exposure in-utero/in-adulthood and robustly associated with cardio-metabolic risk factors. Fund: European Union's Horizon 2020 research and innovation programme under grant agreement no. 633595 DynaHEALTH. (c) 2018 The Authors. Published by Elsevier B.V. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://cris.maastrichtuniversity.nl/en/publications/e402eb71-454e-47e1-a41e-0e1ffbe7eaa0Test |
| DOI: | 10.1016/j.ebiom.2018.10.066 |
| الإتاحة: | https://doi.org/10.1016/j.ebiom.2018.10.066Test https://cris.maastrichtuniversity.nl/en/publications/e402eb71-454e-47e1-a41e-0e1ffbe7eaa0Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.1E6DB8C9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ebiom.2018.10.066 |
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