دورية أكاديمية
Genetics meets epigenetics: Genetic variants that modulate noncoding RNA in cardiovascular diseases
| العنوان: | Genetics meets epigenetics: Genetic variants that modulate noncoding RNA in cardiovascular diseases |
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| المؤلفون: | Calore, Martina, De Windt, Leon J., Rampazzo, Alessandra |
| المصدر: | Calore , M , De Windt , L J & Rampazzo , A 2015 , ' Genetics meets epigenetics: Genetic variants that modulate noncoding RNA in cardiovascular diseases ' , Journal of Molecular and Cellular Cardiology , vol. 89 , pp. 27-34 . https://doi.org/10.1016/j.yjmcc.2015.10.028Test |
| سنة النشر: | 2015 |
| المجموعة: | Maastricht University Research Publications |
| مصطلحات موضوعية: | MiRNAs, Long noncoding RNAs, Cardiovascular diseases, Common genetic variants |
| الوصف: | After the recent description of the human genome by the ENCODE and the FANTOM consortia, major attention has been addressed to the so-called "genomic noise", which mainly consists of noncoding RNAs (ncRNAs). Among them, microRNAs and long non-coding RNAs have been demonstrated to modulate gene expression and to be involved in several human diseases. Since ncRNAs and their targets are encoded in the genome, genetic principles apply. Common variants are supposed to influence the expression level and the functionality of ncRNAs, with subsequent differential regulation of their target genes. Moreover, several reports showed that polymorphisms in ncRNA or their target genes play a role in the development of cardiovascular adverse phenotype. Here, we provide an overview of the effects of these variations in cardiovascular diseases. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1016/j.yjmcc.2015.10.028 |
| الإتاحة: | https://doi.org/10.1016/j.yjmcc.2015.10.028Test https://cris.maastrichtuniversity.nl/en/publications/0ea22212-fa6e-4ac8-bf53-cfe75f93f7b2Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.3919B545 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.yjmcc.2015.10.028 |
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