دورية أكاديمية
Population-Based External Validation of the EASIX Scores to Predict CAR T-Cell-Related Toxicities
| العنوان: | Population-Based External Validation of the EASIX Scores to Predict CAR T-Cell-Related Toxicities |
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| المؤلفون: | de Boer, Janneke W, Keijzer, Kylie, Pennings, Elise R A, van Doesum, Jaap A, Spanjaart, Anne M, Jak, Margot, Mutsaers, Pim G N J, van Dorp, Suzanne, Vermaat, Joost S P, van der Poel, Marjolein W M, van Dijk, Lisanne V, Kersten, Marie José, Niezink, Anne G H, van Meerten, Tom |
| المصدر: | de Boer , J W , Keijzer , K , Pennings , E R A , van Doesum , J A , Spanjaart , A M , Jak , M , Mutsaers , P G N J , van Dorp , S , Vermaat , J S P , van der Poel , M W M , van Dijk , L V , Kersten , M J , Niezink , A G H , van Meerten , T & Dutch CAR T Tumorboard Consortium 2023 , ' Population-Based External Validation of the EASIX Scores to Predict CAR T-Cell-Related Toxicities .... |
| سنة النشر: | 2023 |
| المجموعة: | Maastricht University Research Publications |
| مصطلحات موضوعية: | CAR T-cell therapy, EASIX, LBCL, toxicity |
| الوصف: | Cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) can hamper the clinical benefit of CAR T-cell therapy in patients with relapsed/refractory large B-cell lymphoma (r/r LBCL). To assess the risk of CRS and ICANS, the endothelial activation and stress index (EASIX), the modified EASIX (m-EASIX), simplified EASIX (s-EASIX), and EASIX with CRP/ferritin (EASIX-F(C)) were proposed. This study validates these scores in a consecutive population-based cohort. Patients with r/r LBCL treated with axicabtagene ciloleucel were included ( = 154). EASIX scores were calculated at baseline, before lymphodepletion (pre-LD) and at CAR T-cell infusion. The EASIX and the s-EASIX at pre-LD were significantly associated with ICANS grade = 2 (both = 0.04), and the EASIX approached statistical significance at infusion ( = 0.05). However, the predictive performance was moderate, with area under the curves of 0.61-0.62. Validation of the EASIX-FC revealed that patients in the intermediate risk group had an increased risk of ICANS grade = 2 compared to low-risk patients. No significant associations between EASIX scores and CRS/ICANS grade = 3 were found. The (m-/s-) EASIX can be used to assess the risk of ICANS grade = 2 in patients treated with CAR T-cell therapy. However, due to the moderate performance of the scores, further optimization needs to be performed before broad implementation as a clinical tool, directing early intervention and guiding outpatient CAR T-cell treatment. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://cris.maastrichtuniversity.nl/en/publications/3c548e0c-7c80-4ad8-8fe6-62d67d36ff4aTest |
| DOI: | 10.3390/cancers15225443 |
| الإتاحة: | https://doi.org/10.3390/cancers15225443Test https://cris.maastrichtuniversity.nl/en/publications/3c548e0c-7c80-4ad8-8fe6-62d67d36ff4aTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.2525442 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/cancers15225443 |
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