دورية أكاديمية
Micronutrients, Essential Fatty Acids and Bone Health in Phenylketonuria
| العنوان: | Micronutrients, Essential Fatty Acids and Bone Health in Phenylketonuria |
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| المؤلفون: | Demirdas, Serwet, van Spronsen, Francjan J., Hollak, Carla E. M., van der Lee, J. Hanneke, Bisschop, Peter H., Vaz, Fred M., ter Horst, Nienke M., Rubio-Gozalbo, M. Estela, Bosch, Annet M. |
| المصدر: | Demirdas , S , van Spronsen , F J , Hollak , C E M , van der Lee , J H , Bisschop , P H , Vaz , F M , ter Horst , N M , Rubio-Gozalbo , M E & Bosch , A M 2017 , ' Micronutrients, Essential Fatty Acids and Bone Health in Phenylketonuria ' , Annals of Nutrition and Metabolism , vol. 70 , no. 2 , pp. 111-121 . https://doi.org/10.1159/000465529Test |
| سنة النشر: | 2017 |
| المجموعة: | Maastricht University Research Publications |
| مصطلحات موضوعية: | Phenylketonuria, Micronutrients, Essential fatty acids, Bone mineral density, Phenylalanine, Osteopenia, Osteoporosis, YOUNG-ADULTS, VITAMIN-D, SELENIUM, CHILDREN, DIET, PKU, SUPPLEMENTATION, METAANALYSIS, ADOLESCENTS |
| الوصف: | Introduction: In phenylketonuria (PKU), a natural protein-restricted dietary treatment prevents severe cognitive impairment. Nutrient deficiencies may occur due to strict diet. This study is aimed at evaluating the dietary intake and blood concentrations of micronutrients and essential fatty acids (FA), bone mineral density (BMD) and fracture history in patients on long-term dietary treatment. Methods: Sixty early diagnosed Dutch patients (aged 1-39 years) were included in a multi-center cross-sectional study. Their dietary intake, blood concentrations of micronutrients, FA, fracture history and BMD were assessed. Results: Selenium dietary intake and serum concentrations were low in 14 and 46% of patients, respectively. The serum 25-OH vitamin D2 + D3 concentration was low in 14% of patients while 20% of patients had a low vitamin D intake. Zinc serum concentrations were below normal in 14% of patients, despite adequate intake. Folic acid serum concentrations and intake were elevated. Despite safe total protein and fat intake, arginine plasma concentrations and erythrocyte eicosapentaenoic acid were below reference values in 19 and 6% of patients, respectively. Low BMD (Z-score |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1159/000465529 |
| الإتاحة: | https://doi.org/10.1159/000465529Test https://cris.maastrichtuniversity.nl/en/publications/b8fdea60-b139-4ab6-859a-f90dc9e704c9Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.B9F6D4A0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1159/000465529 |
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