دورية أكاديمية
Intima heterogeneity in stress assessment of atherosclerotic plaques
| العنوان: | Intima heterogeneity in stress assessment of atherosclerotic plaques |
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| المؤلفون: | Akyildiz, Ali C., Speelman, Lambert, van Velzen, Bas, Stevens, Raoul R. F., van der Steen, Antonius F. W., Huberts, Wouter, Gijsen, Frank J. H. |
| المصدر: | Akyildiz , A C , Speelman , L , van Velzen , B , Stevens , R R F , van der Steen , A F W , Huberts , W & Gijsen , F J H 2018 , ' Intima heterogeneity in stress assessment of atherosclerotic plaques ' , Interface Focus , vol. 8 , no. 1 , 20170008 . https://doi.org/10.1098/rsfs.2017.0008Test |
| سنة النشر: | 2018 |
| المجموعة: | Maastricht University Research Publications |
| مصطلحات موضوعية: | atherosclerosis, atherosclerotic plaque stresses, finite-element analysis, heterogeneous plaque properties, global variance-based sensitivity analysis, PULSE-WAVE PROPAGATION, PEAK CAP STRESS, MECHANICAL-PROPERTIES, POLYNOMIAL CHAOS, CORONARY PLAQUE, RUPTURE, INSTABILITY, STABILITY, THICKNESS, ARTERIES |
| الوصف: | / Atherosclerotic plaque rupture is recognized as the primary cause of cardiac and cerebral ischaemic events. High structural plaque stresses have been shown to strongly correlate with plaque rupture. Plaque stresses can be computed with finite-element (FE) models. Current FE models employ homogeneous material properties for the heterogeneous atherosclerotic intima. This study aimed to evaluate the influence of intima heterogeneity on plaque stress computations. Two-dimensional FE models with homogeneous and heterogeneous intima were constructed from histological images of atherosclerotic human coronaries (n = 12). For homogeneous models, a single stiffness valuewas employed for the entire intima. For heterogeneous models, the intima was subdivided into four clusters based on the histological information and different stiffness values were assigned to the clusters. To cover the reported local intima stiffness range, 100 cluster stiffness combinationswere simulated. Peak cap stresses (PCSs) from the homogeneous and heterogeneous models were analysed and compared. By using a global variance-based sensitivity analysis, the influence of the cluster stiffnesses on the PCS variation in the heterogeneous intima models was determined. Per plaque, the median PCS values of the heterogeneous models ranged from 27 to 160 kPa, and the PCS range varied between 43 and 218 kPa. On average, the homogeneous model PCS values differed from the median PCS values of heterogeneous models by 14%. A positive correlation (R-2 = 0.72) was found between the homogeneousmodel PCS and the PCS range of the heterogeneous models. Sensitivity analysis showed that the highest main sensitivity index per plaque ranged from 0.26 to 0.83, and the average was 0.47. Intima heterogeneity resulted in substantial changes in PCS, warranting stress analyses with heterogeneous intima properties for plaque-specific, high accuracy stress assessment. Yet, computations with homogeneous intima assumption are still valuable to perform sensitivity analyses or ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1098/rsfs.2017.0008 |
| الإتاحة: | https://doi.org/10.1098/rsfs.2017.0008Test https://cris.maastrichtuniversity.nl/en/publications/d731024b-4322-4952-a4f0-0c679f56144cTest http://rsfs.royalsocietypublishing.org/content/8/1/20170008.full.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.3CE9E369 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1098/rsfs.2017.0008 |
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