المؤلفون: Simons, Jorik, Agricola, Sandra, Smets, Jeroen, Metz, Renske, Mariani, Silvia, Vleugels, Marie-José, Smeets, Reinier R, van Mook, Walther N K A, Mees, Barend, Lorusso, Roberto

المصدر: Simons , J , Agricola , S , Smets , J , Metz , R , Mariani , S , Vleugels , M-J , Smeets , R R , van Mook , W N K A , Mees , B & Lorusso , R 2022 , ' Duplex Analysis of Cannulated Vessels in Peripheral Veno-Arterial Extracorporeal Membrane Oxygenation ' , Medicina-Lithuania , vol. 58 , no. 5 , 671 . https://doi.org/10.3390/medicina58050671Test

مصطلحات موضوعية: Adult, Extracorporeal Membrane Oxygenation, Femoral Artery/diagnostic imaging, Humans, Ischemia/etiology, Lower Extremity/blood supply, Perfusion, veno-arterial 2, ultrasound 6, ECMO 1, LIMB ISCHEMIA, V-A 3, femoral 4, PRESSURE, ULTRASOUND, duplex 5

الوصف: Background and objectives: Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) cannulas have major repercussions on vascular hemodynamics that can potentially lead to limb ischemia. Duplex ultrasound enables the non-invasive analysis of vascular hemodynamics. This study aims to describe the duplex parameters of the femoral vessels during V-A ECMO support, investigate differences between cannulated and non-cannulated vessels, and analyze the variations in the case of limb ischemia and intra-aortic balloon pumps (IABPs). Methods: Nineteen adults (≥18 years), supported with femoro-femoral V-A ECMO, underwent a duplex analysis of the superficial femoral arteries (SFAs) and veins (FVs). Measured parameters included flow velocities, waveforms, and vessel diameters. Results: 89% of patients had a distal perfusion cannula during duplex analysis and 21% of patients developed limb ischemia. The mean peak systolic flow velocity (PSV) and end-diastolic flow velocity (EDV) of the SFAs on the cannulated side were, respectively, 42.4 and 21.4 cm/s. The SFAs on the non-cannulated side showed a mean PSV and EDV of 87.4 and 19.6 cm/s. All SFAs on the cannulated side had monophasic waveforms, whereas 63% of the SFAs on the non-cannulated side had a multiphasic waveform. Continuous/decreased waveforms were seen in 79% of the FVs on the cannulated side and 61% of the waveforms of the contralateral veins were respirophasic. The mean diameter of the FVs on the cannulated side, in patients who developed limb ischemia, was larger compared to the FVs on the non-cannulated side with a ratio of 1.41 ± 0.12. The group without limb ischemia had a smaller ratio of 1.03 ± 0.25. Conclusions: Femoral cannulas influence flow velocities in the cannulated vessels during V-A ECMO and major waveforms alternations can be seen in all SFAs on the cannulated side and most FVs on the cannulated side. Our data suggest possible venous stasis in the FV on the cannulated side, especially in patients suffering from limb ischemia.

الإتاحة: https://doi.org/10.3390/medicina58050671Test
https://cris.maastrichtuniversity.nl/en/publications/52c135e7-ec94-4cfc-be92-a6ffbbd742f6Test

المؤلفون: Ali Ahmad, Manal, Karavetian, Mirey, Moubareck, Carole Ayoub, Wazz, Gabi, Mahdy, Tarek, Venema, Koen

المصدر: Ali Ahmad , M , Karavetian , M , Moubareck , C A , Wazz , G , Mahdy , T & Venema , K 2022 , ' The Association between Peptide Hormones with Obesity and Insulin Resistance Markers in Lean and Obese Individuals in the United Arab Emirates ' , Nutrients , vol. 14 , no. 6 , 1271 . https://doi.org/10.3390/nu14061271Test

مصطلحات موضوعية: Adult, Body Mass Index, Glucagon-Like Peptide 1, Humans, Insulin Resistance, Obesity, United Arab Emirates, glucagon-like peptide-2, insulin, INTESTINAL MICROBIOTA, GHRELIN, glucagon-like peptide-1, cholecystokinin, CARDIOMETABOLIC RISK-FACTORS, PLASMA, TO-HEIGHT RATIO, brain-gut axis, peptide yy, ADIPOSE-TISSUE, METABOLIC SYNDROME, CCK, leptin, WAIST CIRCUMFERENCE, BODY-MASS INDEX

الوصف: Peptide hormones play a crucial role in body weight and glucose homeostasis. In this study, we aimed to explore this association and recruited 43 obese and 31 age- and sex-matched lean participants. We assessed their body mass index (BMI), waist circumference (WC), waist-to-height ratio (WtHR), percentage body fat (PBF), fasting blood levels of peptide hormones (GLP-1, GLP-2, insulin, leptin, ghrelin, CCK, and PYY), fasting blood sugar (FBS), and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR). We tested the associations between peptide hormones and markers of obesity and insulin resistance (IR) by using the Independent-Samples t-test and Mann-Whitney U test, partial correlation, and logistic regression. FBS, insulin, HOMA-IR, GLP-1, GLP-2, and leptin were significantly higher in the obese group; ghrelin and CCK were significantly higher in lean participants, and no difference was seen for PYY. Controlling for BMI, GLP-1 was positively correlated with WtHR, while ghrelin was inversely correlated with WtHR. GLP-1 was correlated with HOMA-IR. GLP-1 was associated with obesity and IR markers in the regression model. Our results show that obese and lean adults display significant differences in plasma peptide hormone levels. GLP-1 levels were independently associated with markers of obesity and IR. Restoring the appetite hormone balance in obesity may represent a potential therapeutic target.

الإتاحة: https://doi.org/10.3390/nu14061271Test
https://cris.maastrichtuniversity.nl/en/publications/9386dc90-a9c3-496c-82b0-bbc2dce0ecd9Test

المؤلفون: Klein Haneveld, Mirthe J, van Treijen, Mark J C, Pieterman, Carolina R C, Dekkers, Olaf M, van de Ven, Annenienke, de Herder, Wouter W, Zandee, Wouter T, Drent, Madeleine L, Bisschop, Peter H, Havekes, Bas, Vriens, Menno R, Verrijn Stuart, Annemarie A, Valk, Gerlof D, van Leeuwaarde, Rachel S

المصدر: Klein Haneveld , M J , van Treijen , M J C , Pieterman , C R C , Dekkers , O M , van de Ven , A , de Herder , W W , Zandee , W T , Drent , M L , Bisschop , P H , Havekes , B , Vriens , M R , Verrijn Stuart , A A , Valk , G D & van Leeuwaarde , R S 2021 , ' Initiating Pancreatic Neuroendocrine Tumor (pNET) Screening in Young MEN1 Patients : Results From the DutchMEN Study Group ' , Journal ....

مصطلحات موضوعية: Adolescent, Adult, Age of Onset, Aged, Child, Preschool, Databases, Factual, Diagnostic Imaging, Early Detection of Cancer/methods, Female, Follow-Up Studies, Humans, Male, Middle Aged, Multiple Endocrine Neoplasia Type 1/physiopathology, Netherlands/epidemiology, Neuroendocrine Tumors/diagnosis, Pancreatic Neoplasms/diagnosis, Prognosis, Retrospective Studies, Survival Rate, Tumor Burden, Young Adult, ENDOCRINE NEOPLASIA TYPE-1, INTERVAL-CENSORED-DATA, surveillance, multiple endocrine neoplasia type 1, age-related penetrance, pancreatic NET

الوصف: CONTEXT: Nonfunctioning pancreatic neuroendocrine tumors (NF-pNETs) are highly prevalent and constitute an important cause of mortality in patients with multiple endocrine neoplasia type 1 (MEN1). Still, the optimal age to initiate screening for pNETs is under debate. OBJECTIVE: The aim of this work is to assess the age of occurrence of clinically relevant NF-pNETs in young MEN1 patients. METHODS: Pancreatic imaging data of MEN1 patients were retrieved from the DutchMEN Study Group database. Interval-censored survival methods were used to describe age-related penetrance, compare survival curves, and develop a parametric model for estimating the risk of having clinically relevant NF-pNET at various ages. The primary objective was to assess age at occurrence of clinically relevant NF-pNET (size ≥ 20 mm or rapid growth); secondary objectives were the age at occurrence of NF-pNET of any size and pNET-associated metastasized disease. RESULTS: Five of 350 patients developed clinically relevant NF-pNETs before age 18 years, 2 of whom subsequently developed lymph node metastases. No differences in clinically relevant NF-pNET-free survival were found for sex, time frame, and type of MEN1 diagnosis or genotype. The estimated ages (median, 95% CI) at a 1%, 2.5%, and 5% risk of having developed a clinically relevant tumor are 9.5 (6.5-12.7), 13.5 (10.2-16.9), and 17.8 years (14.3-21.4), respectively. CONCLUSION: Analyses from this population-based cohort indicate that start of surveillance for NF-pNETs with pancreatic imaging at age 13 to 14 years is justified. The psychological and medical burden of screening at a young age should be considered.

الإتاحة: https://doi.org/10.1210/clinem/dgab569Test
https://cris.maastrichtuniversity.nl/en/publications/b4e76abf-f1e2-4a83-99e7-5808d22c1cdcTest