دورية أكاديمية
The Association between Peptide Hormones with Obesity and Insulin Resistance Markers in Lean and Obese Individuals in the United Arab Emirates
| العنوان: | The Association between Peptide Hormones with Obesity and Insulin Resistance Markers in Lean and Obese Individuals in the United Arab Emirates |
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| المؤلفون: | Ali Ahmad, Manal, Karavetian, Mirey, Moubareck, Carole Ayoub, Wazz, Gabi, Mahdy, Tarek, Venema, Koen |
| المصدر: | Ali Ahmad , M , Karavetian , M , Moubareck , C A , Wazz , G , Mahdy , T & Venema , K 2022 , ' The Association between Peptide Hormones with Obesity and Insulin Resistance Markers in Lean and Obese Individuals in the United Arab Emirates ' , Nutrients , vol. 14 , no. 6 , 1271 . https://doi.org/10.3390/nu14061271Test |
| سنة النشر: | 2022 |
| المجموعة: | Maastricht University Research Publications |
| مصطلحات موضوعية: | Adult, Body Mass Index, Glucagon-Like Peptide 1, Humans, Insulin Resistance, Obesity, United Arab Emirates, glucagon-like peptide-2, insulin, INTESTINAL MICROBIOTA, GHRELIN, glucagon-like peptide-1, cholecystokinin, CARDIOMETABOLIC RISK-FACTORS, PLASMA, TO-HEIGHT RATIO, brain-gut axis, peptide yy, ADIPOSE-TISSUE, METABOLIC SYNDROME, CCK, leptin, WAIST CIRCUMFERENCE, BODY-MASS INDEX |
| الوصف: | Peptide hormones play a crucial role in body weight and glucose homeostasis. In this study, we aimed to explore this association and recruited 43 obese and 31 age- and sex-matched lean participants. We assessed their body mass index (BMI), waist circumference (WC), waist-to-height ratio (WtHR), percentage body fat (PBF), fasting blood levels of peptide hormones (GLP-1, GLP-2, insulin, leptin, ghrelin, CCK, and PYY), fasting blood sugar (FBS), and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR). We tested the associations between peptide hormones and markers of obesity and insulin resistance (IR) by using the Independent-Samples t-test and Mann-Whitney U test, partial correlation, and logistic regression. FBS, insulin, HOMA-IR, GLP-1, GLP-2, and leptin were significantly higher in the obese group; ghrelin and CCK were significantly higher in lean participants, and no difference was seen for PYY. Controlling for BMI, GLP-1 was positively correlated with WtHR, while ghrelin was inversely correlated with WtHR. GLP-1 was correlated with HOMA-IR. GLP-1 was associated with obesity and IR markers in the regression model. Our results show that obese and lean adults display significant differences in plasma peptide hormone levels. GLP-1 levels were independently associated with markers of obesity and IR. Restoring the appetite hormone balance in obesity may represent a potential therapeutic target. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.3390/nu14061271 |
| الإتاحة: | https://doi.org/10.3390/nu14061271Test https://cris.maastrichtuniversity.nl/en/publications/9386dc90-a9c3-496c-82b0-bbc2dce0ecd9Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.3B31552F |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/nu14061271 |
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