دورية أكاديمية
Apolipoprotein E genotypes and longevity across dementia disorders
| العنوان: | Apolipoprotein E genotypes and longevity across dementia disorders |
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| المؤلفون: | Skillbäck, Tobias, Lautner, Ronald, Mattsson, Niklas, Schott, Jonathan M., Nägga, Katarina, Kilander, Lena, Wimo, Anders, Winblad, Bengt, Eriksdotter, Maria, Blennow, Kaj, Zetterberg, Henrik |
| المصدر: | Alzheimer's and Dementia; 14(7), pp 895-901 (2018) ; ISSN: 1552-5260 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2018 |
| المجموعة: | Lund University Publications (LUP) |
| مصطلحات موضوعية: | Neurology, Alzheimer's disease, Apolipoprotein E, Creutzfeldt-Jakob disease, Dementia with Lewy bodies, Frontotemporal dementia, Parkinson's disease dementia, Vascular dementia |
| الوصف: | Introduction: The ε4 allele of the apolipoprotein E (APOE) gene is a prominent risk factor for Alzheimer's disease (AD), but its implication in other dementias is less well studied. Methods: We used a data set on 2858 subjects (1098 AD, 260 vascular dementia [VaD], 145 mixed AD and VaD, 90 other dementia diagnoses, and 1265 controls) to examine the association of APOE polymorphisms with clinical dementia diagnoses, biomarker profiles, and longevity. Results: The ε4 allele was associated with reduced longevity as ε4 versus ε3 homozygotes lived on average 2.6 years shorter (P =.006). In AD, ε4 carriers lived 1.0 years shorter than noncarriers (P =.028). The ε4 allele was more prevalent in AD, mixed AD and VaD, and VaD patients compared to controls, but not in other dementia disorders. Discussion: The APOE ε4 allele is influential in AD but might also be of importance in VaD and in mixed AD and VaD, diseases in which concomitant AD pathology is common. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://lup.lub.lu.se/record/d45e54a9-1660-4eed-8821-f5b4ff7808dfTest; http://dx.doi.org/10.1016/j.jalz.2018.02.003Test; pmid:29548722; scopus:85045326265 |
| DOI: | 10.1016/j.jalz.2018.02.003 |
| الإتاحة: | https://doi.org/10.1016/j.jalz.2018.02.003Test https://lup.lub.lu.se/record/d45e54a9-1660-4eed-8821-f5b4ff7808dfTest |
| رقم الانضمام: | edsbas.481BBDC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jalz.2018.02.003 |
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