دورية أكاديمية
Past and current cause-specific mortality in Eisenmenger syndrome
| العنوان: | Past and current cause-specific mortality in Eisenmenger syndrome |
|---|---|
| المؤلفون: | Hjortshoj, Cristel M.Sorensen, Kempny, Aleksander, Jensen, Annette Schophuus, Sorensen, Keld, Nagy, Edit, Dellborg, Mikael, Johansson, Bengt, Rudiene, Virginija, Hong, Gu, Opotowsky, Alexander R., Budts, Werner, Mulder, Barbara J., Tomkiewicz-Pająk, Lidia, D'Alto, Michele, Prokselj, Katja, Diller, Gerhard Paul, Dimopoulos, Konstantinos, Estensen, Mette Elise, Holmstrom, Henrik, Turanlahti, Maila, Thilén, Ulf, Gatzoulis, Michael A., Sondergaard, And Lars |
| المصدر: | European Heart Journal; 38(26), pp 2060-2067 (2017) ; ISSN: 0195-668X |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2017 |
| المجموعة: | Lund University Publications (LUP) |
| مصطلحات موضوعية: | Cardiac and Cardiovascular Systems, Cause of death, Eisenmenger syndrome, Heart failure, Mortality, Pulmonary arterial hypertension |
| الوصف: | Aims: Eisenmenger syndrome (ES) is associated with considerable morbidity and mortality. Therapeutic strategies have changed during the 2000s in conjunction with an emphasis on specialist follow-up. The aim of this study was to determine the cause-specific mortality in ES and evaluate any relevant changes between 1977 and 2015. Methods and results: This is a retrospective, descriptive multicentre study. A total of 1546 patients (mean age 38.7 ± 15.4 years; 36% male) from 13 countries were included. Cause-specific mortality was examined before and after July 2006, 'early' and 'late', respectively. Over a median follow-up of 6.1 years (interquartile range 2.1-21.5 years) 558 deaths were recorded; cause-specific mortality was identified in 411 (74%) cases. Leading causes of death were heart failure (34%), infection (26%), sudden cardiac death (10%), thromboembolism (8%), haemorrhage (7%), and peri-procedural (7%). Heart failure deaths increased in the 'late' relative to the 'early' era (P = 0.032), whereas death from thromboembolic events and death in relation to cardiac and non-cardiac procedures decreased (P = 0.014, P = 0.014, P = 0.004, respectively). There was an increase in longevity in the 'late' vs. 'early' era (median survival 52.3 vs. 35.2 years, P < 0.001). Conclusion: The study shows that despite changes in therapy, care, and follow-up of ES in tertiary care centres, all-cause mortality including cardiac remains high. Patients from the 'late' era, however, die later and from chronic rather than acute cardiac causes, primarily heart failure, whereas peri-procedural and deaths due to haemoptysis have become less common. Lifelong vigilance in tertiary centres and further research for ES are clearly needed. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://lup.lub.lu.se/record/ab4431c6-f896-44c3-9f5d-c1c8f1ce1e10Test; http://dx.doi.org/10.1093/eurheartj/ehx201Test; scopus:85026506781; pmid:28430906; wos:000404987200011 |
| DOI: | 10.1093/eurheartj/ehx201 |
| الإتاحة: | https://doi.org/10.1093/eurheartj/ehx201Test https://lup.lub.lu.se/record/ab4431c6-f896-44c3-9f5d-c1c8f1ce1e10Test |
| رقم الانضمام: | edsbas.749CCC82 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/eurheartj/ehx201 |
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