المؤلفون: Zewinger, Stephen, Kleber, Marcus E, Tragante, Vinicius, McCubrey, Raymond O., Schmidt, Amand F., Direk, Kenan, Laufs, Ulrich, Werner, Christian, Koenig, Wolfgang, Rothenbacher, Dietrich, Mons, Ute, Breitling, Lutz P., Brenner, Herrmann, Jennings, Richard T., Petrakis, Ioannis, Triem, Sarah, Klug, Mira, Filips, Alexandra, Blankenberg, Stefan, Waldeyer, Christoph, Sinning, Christoph R., Schnabel, Renate B, Lackner, Karl J., Vlachopoulou, Efthymia, Nygård, Ottar, Svingen, Gard Frodahl Tveitevåg, Pedersen, Eva Ringdal, Tell, Grethe S., Sinisalo, Juha, Nieminen, Markku S., Laaksonen, Reijo, Trompet, Stella, Smit, Roelof A.J., Sattar, Naveed, Jukema, J Wouter, Groesdonk, Heinrich V., Delgado, Graciela, Stojakovic, Tatjana, Pilbrow, Anna P., Cameron, Vicky A., Richards, A. Mark, Doughty, Robert N., Gong, Yan, Cooper-Dehoff, Rhonda M, Johnson, Julie A., Scholz, Markus, Beutner, Frank, Thiery, Joachim, Smith, Gustav, Vilmundarson, Ragnar O., McPherson, Ruth, Stewart, Alexandre F. R., Cresci, Sharon, Lenzini, Petra A., Spertus, John A., Olivieri, Oliviero, Girelli, Domenico, Martinelli, Nicola I., Leiherer, Andreas, Saely, Christoph H., Drexel, Heinz, Mündlein, Axel, Braund, Peter S., Nelson, Christopher P, Samani, Nilesh J., Kofink, Daniel, Hoefer, Imo E, Pasterkamp, Gerard, Quyyumi, Arshed A., Ko, Yi An, Hartiala, Jaana A., Allayee, Hooman, Tang, W. H. Wilson, Hazen, Stanley L., Eriksson, Niclas, Held, Claes, Hagström, Emil, Wallentin, Lars, Åkerblom, Axel, Siegbahn, Agneta, Karp, Igor, Labos, Christopher, Pilote, Louise, Engert, James C, Brophy, James M., Thanassoulis, George, Bogaty, Peter, Szczeklik, Wojciech, Kaczor, Marcin, Sanak, Marek, Virani, Salim S., Ballantyne, Christie M, Lee, Vei Vei, Boerwinkle, Eric, Holmes, Michael V, Horne, Benjamin D., Hingorani, Aroon, Asselbergs, Folkert W., Patel, Riyaz S., Krämer, Bernhard K., Scharnagl, Hubert, Fliser, Danilo, März, Winfried, Speer, Thimoteus

المصدر: The Lancet Diabetes and Endocrinology; 5(7), pp 534-543 (2017) ; ISSN: 2213-8587

مصطلحات موضوعية: Cardiac and Cardiovascular Systems

الوصف: Background: Lipoprotein(a) concentrations in plasma are associated with cardiovascular risk in the general population. Whether lipoprotein(a) concentrations or LPA genetic variants predict long-term mortality in patients with established coronary heart disease remains less clear. Methods: We obtained data from 3313 patients with established coronary heart disease in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. We tested associations of tertiles of lipoprotein(a) concentration in plasma and two LPA single-nucleotide polymorphisms ([SNPs] rs10455872 and rs3798220) with all-cause mortality and cardiovascular mortality by Cox regression analysis and with severity of disease by generalised linear modelling, with and without adjustment for age, sex, diabetes diagnosis, systolic blood pressure, BMI, smoking status, estimated glomerular filtration rate, LDL-cholesterol concentration, and use of lipid-lowering therapy. Results for plasma lipoprotein(a) concentrations were validated in five independent studies involving 10 195 patients with established coronary heart disease. Results for genetic associations were replicated through large-scale collaborative analysis in the GENIUS-CHD consortium, comprising 106 353 patients with established coronary heart disease and 19 332 deaths in 22 studies or cohorts. Findings: The median follow-up was 9·9 years. Increased severity of coronary heart disease was associated with lipoprotein(a) concentrations in plasma in the highest tertile (adjusted hazard radio [HR] 1·44, 95% CI 1·14-1·83) and the presence of either LPA SNP (1·88, 1·40-2·53). No associations were found in LURIC with all-cause mortality (highest tertile of lipoprotein(a) concentration in plasma 0·95, 0·81-1·11 and either LPA SNP 1·10, 0·92-1·31) or cardiovascular mortality (0·99, 0·81-1·2 and 1·13, 0·90-1·40, respectively) or in the validation studies. Interpretation: In patients with prevalent coronary heart disease, lipoprotein(a) concentrations and genetic variants showed no associations with ...

العلاقة: https://lup.lub.lu.se/record/090d445f-f2d3-40b8-b9c9-abe964a82c78Test; http://dx.doi.org/10.1016/S2213-8587Test(17)30096-7; wos:000403672400019; scopus:85019743146

الإتاحة: https://doi.org/10.1016/S2213-8587Test(17)30096-7
https://lup.lub.lu.se/record/090d445f-f2d3-40b8-b9c9-abe964a82c78Test

المؤلفون: Kato, Norihiro, Loh, Marie, Takeuchi, Fumihiko, Verweij, Niek, Wang, Xu, Zhang, Weihua, Kelly, Tanika N, Saleheen, Danish, Lehne, Benjamin, Leach, Irene Mateo, Drong, Alexander W, Abbott, James, Wahl, Simone, Tan, Sian-Tsung, Scott, William R, Campanella, Gianluca, Chadeau-Hyam, Marc, Afzal, Uzma, Ahluwalia, Tarunveer S, Bonder, Marc Jan, Chen, Peng, Dehghan, Abbas, Edwards, Todd L, Esko, Tõnu, Go, Min Jin, Harris, Sarah E, Hartiala, Jaana, Kasela, Silva, Kasturiratne, Anuradhani, Khor, Chiea-Chuen, Kleber, Marcus E, Li, Huaixing, Mok, Zuan Yu, Nakatochi, Masahiro, Sapari, Nur Sabrina, Saxena, Richa, Stewart, Alexandre F R, Stolk, Lisette, Tabara, Yasuharu, Teh, Ai Ling, Wu, Ying, Wu, Jer-Yuarn, Zhang, Yi, Aits, Imke, Da Silva Couto Alves, Alexessander, Das, Shikta, Dorajoo, Rajkumar, Hopewell, Jemma C, Kim, Yun Kyoung, Koivula, Robert, Luan, Jian'an, Lyytikäinen, Leo-Pekka, Nguyen, Quang N, Pereira, Mark A, Postmus, Iris, Raitakari, Olli T, Bryan, Molly Scannell, Scott, Robert A, Sorice, Rossella, Tragante, Vinicius, Traglia, Michela, White, Jon, Yamamoto, Ken, Zhang, Yonghong, Adair, Linda S, Ahmed, Alauddin, Akiyama, Koichi, Asif, Rasheed, Aung, Tin, Barroso, Inês, Bjonnes, Andrew, Braun, Timothy R, Cai, Hui, Chang, Li-Ching, Chen, Chien-Hsiun, Cheng, Ching-Yu, Chong, Yap-Seng, Collins, Rory, Courtney, Regina, Davies, Gail, Delgado, Graciela, Do, Loi D, Doevendans, Pieter A, Gansevoort, Ron T, Gao, Yu-Tang, Grammer, Tanja B, Grarup, Niels, Grewal, Jagvir, Gu, Dongfeng, Wander, Gurpreet S, Hartikainen, Anna-Liisa, Hazen, Stanley L, He, Jing, Heng, Chew-Kiat, Hixson, James E, Hofman, Albert, Hsu, Chris, Huang, Wei, Husemoen, Lise L N, Hwang, Joo-Yeon, Ichihara, Sahoko, Igase, Michiya, Isono, Masato, Justesen, Johanne M, Katsuya, Tomohiro, Kibriya, Muhammad G, Kim, Young Jin, Kishimoto, Miyako, Koh, Woon-Puay, Kohara, Katsuhiko, Kumari, Meena, Kwek, Kenneth, Lee, Nanette R, Lee, Jeannette, Liao, Jiemin, Lieb, Wolfgang, Liewald, David C M, Matsubara, Tatsuaki, Matsushita, Yumi, Meitinger, Thomas, Mihailov, Evelin, Milani, Lili, Mills, Rebecca, Mononen, Nina, Müller-Nurasyid, Martina, Nabika, Toru, Nakashima, Eitaro, Ng, Hong Kiat, Nikus, Kjell, Nutile, Teresa, Ohkubo, Takayoshi, Ohnaka, Keizo, Parish, Sarah, Paternoster, Lavinia, Peng, Hao, Peters, Annette, Pham, Son T, Pinidiyapathirage, Mohitha J, Rahman, Mahfuzar, Rakugi, Hiromi, Rolandsson, Olov, Rozario, Michelle Ann, Ruggiero, Daniela, Sala, Cinzia F, Sarju, Ralhan, Shimokawa, Kazuro, Snieder, Harold, Sparsø, Thomas, Spiering, Wilko, Starr, John M, Stott, David J, Stram, Daniel O, Sugiyama, Takao, Szymczak, Silke, Tang, W H Wilson, Tong, Lin, Trompet, Stella, Turjanmaa, Väinö, Ueshima, Hirotsugu, Uitterlinden, André G, Umemura, Satoshi, Vaarasmaki, Marja, van Dam, Rob M, van Gilst, Wiek H, van Veldhuisen, Dirk J, Viikari, Jorma S, Waldenberger, Melanie, Wang, Yiqin, Wang, Aili, Wilson, Rory, Wong, Tien-Yin, Xiang, Yong-Bing, Yamaguchi, Shuhei, Ye, Xingwang, Young, Robin D, Young, Terri L, Yuan, Jian-Min, Zhou, Xueya, Asselbergs, Folkert W, Ciullo, Marina, Clarke, Robert, Deloukas, Panos, Franke, Andre, Franks, Paul, Franks, Steve, Friedlander, Yechiel, Gross, Myron D, Guo, Zhirong, Hansen, Torben, Jarvelin, Marjo-Riitta, Jørgensen, Torben, Jukema, J Wouter, Kähönen, Mika, Kajio, Hiroshi, Kivimaki, Mika, Lee, Jong-Young, Lehtimäki, Terho, Linneberg, Allan, Miki, Tetsuro, Pedersen, Oluf, Samani, Nilesh J, Sørensen, Thorkild I A, Takayanagi, Ryoichi, Toniolo, Daniela, Ahsan, Habibul, Allayee, Hooman, Chen, Yuan-Tsong, Danesh, John, Deary, Ian J, Franco, Oscar H, Franke, Lude, Heijman, Bastiaan T, Holbrook, Joanna D, Isaacs, Aaron, Kim, Bong-Jo, Lin, Xu, Liu, Jianjun, März, Winfried, Metspalu, Andres, Mohlke, Karen L, Sanghera, Dharambir K, Shu, Xiao-Ou, van Meurs, Joyce B J, Vithana, Eranga, Wickremasinghe, Ananda R, Wijmenga, Cisca, Wolffenbuttel, Bruce H W, Yokota, Mitsuhiro, Zheng, Wei, Zhu, Dingliang, Vineis, Paolo, Kyrtopoulos, Soterios A, Kleinjans, Jos C S, McCarthy, Mark I, Soong, Richie, Gieger, Christian, Scott, James, Teo, Yik-Ying, He, Jiang, Elliott, Paul, Tai, E Shyong, van der Harst, Pim, Kooner, Jaspal S, Chambers, John C

المصدر: Nature Genetics; 47(11), pp 93-1282 (2015) ; ISSN: 1546-1718

مصطلحات موضوعية: Medical Genetics

الوصف: We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10(-11) to 5.0 × 10(-21)). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the regulatory pathway linking sequence variation to blood pressure. The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function. The new and known genetic variants predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and all-cause mortality (P = 0.04 to 8.6 × 10(-6)). Our results provide new evidence for the role of DNA methylation in blood pressure regulation.

العلاقة: https://lup.lub.lu.se/record/8035521Test; http://dx.doi.org/10.1038/ng.3405Test; pmid:26390057; wos:000363988200012; scopus:84965118964

الإتاحة: https://doi.org/10.1038/ng.3405Test
https://lup.lub.lu.se/record/8035521Test

المؤلفون: van der Harst, Pim, Zhang, Weihua, Leach, Irene Mateo, Rendon, Augusto, Verweij, Niek, Sehmi, Joban, Paul, Dirk S., Elling, Ulrich, Allayee, Hooman, Li, Xinzhong, Radhakrishnan, Aparna, Tan, Sian-Tsung, Voss, Katrin, Weichenberger, Christian X., Albers, Cornelis A., Al-Hussani, Abtehale, Asselbergs, Folkert W., Ciullo, Marina, Danjou, Fabrice, Dina, Christian, Esko, Tonu, Evans, David M., Franke, Lude, Goegele, Martin, Hartiala, Jaana, Hersch, Micha, Holm, Hilma, Hottenga, Jouke-Jan, Kanoni, Stavroula, Kleber, Marcus E., Lagou, Vasiliki, Langenberg, Claudia, Lopez, Lorna M., Lyytikainen, Leo-Pekka, Melander, Olle, Murgia, Federico, Nolte, Ilja M., O'Reilly, Paul F., Padmanabhan, Sandosh, Parsa, Afshin, Pirastu, Nicola, Porcu, Eleonora, Portas, Laura, Prokopenko, Inga, Ried, Janina S., Shin, So-Youn, Tang, Clara S., Teumer, Alexander, Traglia, Michela, Ulivi, Sheila, Westra, Harm-Jan, Yang, Jian, Zhao, Jing Hua, Anni, Franco, Abdellaoui, Abdel, Attwood, Antony, Balkau, Beverley, Bandinelli, Stefania, Bastardot, Francois, Benyamin, Beben, Boehm, Bernhard O., Cookson, William O., Das, Debashish, de Bakker, Paul I. W., de Boer, Rudolf A., de Geus, Eco J. C., de Moor, Marleen H., Dimitriou, Maria, Domingues, Francisco S., Doering, Angela, Engström, Gunnar, Eyjolfsson, Gudmundur Ingi, Ferrucci, Luigi, Fischer, Krista, Galanello, Renzo, Garner, Stephen F., Genser, Bernd, Gibson, Quince D., Girotto, Giorgia, Gudbjartsson, Daniel Fannar, Harris, Sarah E., Hartikainen, Anna-Liisa, Hastie, Claire E., Hedblad, Bo, Illig, Thomas, Jolley, Jennifer, Kahonen, Mika, Kema, Ido P., Kemp, John P., Liang, Liming, Lloyd-Jones, Heather, Loos, Ruth J. F., Meacham, Stuart, Medland, Sarah E., Meisinger, Christa, Memari, Yasin, Mihailov, Evelin, Miller, Kathy, Moffatt, Miriam F., Nauck, Matthias, Novatchkova, Maria, Nutile, Teresa, Olafsson, Isleifur, Onundarson, Pall T., Parracciani, Debora, Penninx, Brenda W., Perseu, Lucia, Piga, Antonio, Pistis, Giorgio, Pouta, Anneli, Puc, Ursula, Raitakari, Olli, Ring, Susan M., Robino, Antonietta, Ruggiero, Daniela, Ruokonen, Aimo, Saint-Pierre, Aude, Sala, Cinzia, Salumets, Andres, Sambrook, Jennifer, Schepers, Hein, Schmidt, Carsten Oliver, Sillje, Herman H. W., Sladek, Rob, Smit, Johannes H., Starr, John M., Stephens, Jonathan, Sulem, Patrick, Tanaka, Toshiko, Thorsteinsdottir, Unnur, Tragante, Vinicius, van Gilst, Wiek H., van Pelt, L. Joost, van Veldhuisen, Dirk J., Voelker, Uwe, Whitfield, John B., Willemsen, Gonneke, Winkelmann, Bernhard R., Wirnsberger, Gerald, Algra, Ale, Cucca, Francesco, d'Adamo, Adamo Pio, Danesh, John, Deary, Ian J., Dominiczak, Anna F., Elliott, Paul, Fortina, Paolo, Froguel, Philippe, Gasparini, Paolo, Greinacher, Andreas, Hazen, Stanley L., Jarvelin, Marjo-Riitta, Khaw, Kay Tee, Lehtimaki, Terho, Maerz, Winfried, Martin, Nicholas G., Metspalu, Andres, Mitchell, Braxton D., Montgomery, Grant W., Moore, Carmel, Navis, Gerjan, Pirastu, Mario, Pramstaller, Peter P., Ramirez-Solis, Ramiro, Schadt, Eric, Scott, James, Shuldiner, Alan R., Smith, George Davey, Smith, Gustav, Snieder, Harold, Sorice, Rossella, Spector, Tim D., Stefansson, Kari, Stumvoll, Michael, Tang, W. H. Wilson, Toniolo, Daniela, Toenjes, Anke, Visscher, Peter M., Vollenweider, Peter, Wareham, Nicholas J., Wolffenbuttel, Bruce H. R., Boomsma, Dorret I., Beckmann, Jacques S., Dedoussis, George V., Deloukas, Panos, Ferreira, Manuel A., Sanna, Serena, Uda, Manuela, Hicks, Andrew A., Penninger, Josef Martin, Gieger, Christian, Kooner, Jaspal S., Ouwehand, Willem H., Soranzo, Nicole, Chambers, John C.

المصدر: Nature; 492(7429), pp 369-375 (2012) ; ISSN: 0028-0836

مصطلحات موضوعية: Cardiac and Cardiovascular Systems

الوصف: Anaemia is a chief determinant of global ill health, contributing to cognitive impairment, growth retardation and impaired physical capacity. To understand further the genetic factors influencing red blood cells, we carried out a genome-wide association study of haemoglobin concentration and related parameters in up to 135,367 individuals. Here we identify 75 independent genetic loci associated with one or more red blood cell phenotypes at P < 10(-8), which together explain 4-9% of the phenotypic variance per trait. Using expression quantitative trait loci and bioinformatic strategies, we identify 121 candidate genes enriched in functions relevant to red blood cell biology. The candidate genes are expressed preferentially in red blood cell precursors, and 43 have haematopoietic phenotypes in Mus musculus or Drosophila melanogaster. Through open-chromatin and coding-variant analyses we identify potential causal genetic variants at 41 loci. Our findings provide extensive new insights into genetic mechanisms and biological pathways controlling red blood cell formation and function.

العلاقة: https://lup.lub.lu.se/record/3366396Test; http://dx.doi.org/10.1038/nature11677Test; wos:000312488200044; scopus:84871464519; pmid:23222517

الإتاحة: https://doi.org/10.1038/nature11677Test
https://lup.lub.lu.se/record/3366396Test

المؤلفون: Schunkert, Heribert, Koenig, Inke R., Kathiresan, Sekar, Reilly, Muredach P., Assimes, Themistocles L., Holm, Hilma, Preuss, Michael, Stewart, Alexandre F. R., Barbalic, Maja, Gieger, Christian, Absher, Devin, Aherrahrou, Zouhair, Allayee, Hooman, Altshuler, David, Anand, Sonia S., Andersen, Karl, Anderson, Jeffrey L., Ardissino, Diego, Ball, Stephen G., Balmforth, Anthony J., Barnes, Timothy A., Becker, Diane M., Becker, Lewis C., Berger, Klaus, Bis, Joshua C., Boekholdt, S. Matthijs, Boerwinkle, Eric, Braund, Peter S., Brown, Morris J., Burnett, Mary Susan, Buysschaert, Ian, Carlquist, John F., Chen, Li, Cichon, Sven, Codd, Veryan, Davies, Robert W., Dedoussis, George, Dehghan, Abbas, Demissie, Serkalem, Devaney, Joseph M., Diemert, Patrick, Do, Ron, Doering, Angela, Eifert, Sandra, El Mokhtari, Nour Eddine, Ellis, Stephen G., Elosua, Roberto, Engert, James C., Epstein, Stephen E., de Faire, Ulf, Fischer, Marcus, Folsom, Aaron R., Freyer, Jennifer, Gigante, Bruna, Girelli, Domenico, Gretarsdottir, Solveig, Gudnason, Vilmundur, Gulcher, Jeffrey R., Halperin, Eran, Hammond, Naomi, Hazen, Stanley L., Hofman, Albert, Horne, Benjamin D., Illig, Thomas, Iribarren, Carlos, Jones, Gregory T., Jukema, J. Wouter, Kaiser, Michael A., Kaplan, Lee M., Kastelein, John J. P., Khaw, Kay-Tee, Knowles, Joshua W., Kolovou, Genovefa, Kong, Augustine, Laaksonen, Reijo, Lambrechts, Diether, Leander, Karin, Lettre, Guillaume, Li, Mingyao, Lieb, Wolfgang, Loley, Christina, Lotery, Andrew J., Mannucci, Pier M., Maouche, Seraya, Martinelli, Nicola, McKeown, Pascal P., Meisinger, Christa, Meitinger, Thomas, Melander, Olle, Merlini, Pier Angelica, Mooser, Vincent, Morgan, Thomas, Muehleisen, Thomas W., Muhlestein, Joseph B., Muenzel, Thomas, Musunuru, Kiran, nahrstaedt, Janja, Nelson, Christopher P., Noethen, Markus M., Olivieri, Oliviero, Patel, Riyaz S., Patterson, Chris C., Peters, Annette, Peyvandi, Flora, Qu, Liming, Quyyumi, Arshed A., Rader, Daniel J., Rallidis, Loukianos S., Rice, Catherine, Rosendaal, Frits R., Rubin, Diana, Salomaa, Veikko, Sampietro, M. Lourdes, Sandhu, Manj S., Schadt, Eric, Schaefer, Arne, Schillert, Arne, Schreiber, Stefan, Schrezenmeir, Juergen, Schwartz, Stephen M., Siscovick, David S., Sivananthan, Mohan, Sivapalaratnam, Suthesh, Smith, Albert, Smith, Tamara B., Snoep, Jaapjan D., Soranzo, Nicole, Spertus, John A., Stark, Klaus, Stirrups, Kathy, Stoll, Monika, Tang, W. H. Wilson, Tennstedt, Stephanie, Thorgeirsson, Gudmundur, Thorleifsson, Gudmar, Tomaszewski, Maciej, Uitterlinden, Andre G., van Rij, Andre M., Voight, Benjamin F., Wareham, Nick J., Wells, George A., Wichmann, H-Erich, Wild, Philipp S., Willenborg, Christina, Witteman, Jaqueline C. M., Wright, Benjamin J., Ye, Shu, Zeller, Tanja, Ziegler, Andreas, Cambien, Francois, Goodall, Alison H., Cupples, L. Adrienne, Quertermous, Thomas, Maerz, Winfried, Hengstenberg, Christian, Blankenberg, Stefan, Ouwehand, Willem H., Hall, Alistair S., Deloukas, Panos, Thompson, John R., Stefansson, Kari, Roberts, Robert, Thorsteinsdottir, Unnur, O'Donnell, Christopher J., McPherson, Ruth, Erdmann, Jeanette, Samani, Nilesh J.

المصدر: Nature Genetics; 43(4), pp 153-333 (2011) ; ISSN: 1546-1718

مصطلحات موضوعية: Cardiac and Cardiovascular Systems

الوصف: We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 x 10(-8) and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.

العلاقة: https://lup.lub.lu.se/record/1925030Test; http://dx.doi.org/10.1038/ng.784Test; wos:000288903700013; scopus:79953204259; pmid:21378990

الإتاحة: https://doi.org/10.1038/ng.784Test
https://lup.lub.lu.se/record/1925030Test