دورية أكاديمية
Factors Associated With Circulating Sex Hormones in Men
| العنوان: | Factors Associated With Circulating Sex Hormones in Men |
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| المؤلفون: | Marriott, Ross J., Murray, Kevin, Adams, Robert J., Antonio, Leen, Ballantyne, Christie M., Bauer, Douglas C., Bhasin, Shalender, Biggs, Mary L., Cawthon, Peggy M., Couper, David J., Dobs, Adrian S., Flicker, Leon, Handelsman, David J., Hankey, Graeme J., Hannemann, Anke, Haring, Robin, Hsu, Benjumin, Karlsson, Magnus, Martin, Sean A., Matsumoto, Alvin M., Mellström, Dan, Ohlsson, Claes, O'Neill, Terence W, Orwoll, Eric S., Quartagno, Matteo, Shores, Molly M., Steveling, Antje, Tivesten, Åsa, Travison, Thomas G., Vanderschueren, Dirk, Wittert, Gary A., Wu, Frederick C.W., Yeap, Bu B. |
| المصدر: | Annals of Internal Medicine; 176(9), pp 1221-1234 (2023) ; ISSN: 0003-4819 |
| بيانات النشر: | American College of Physicians |
| سنة النشر: | 2023 |
| المجموعة: | Lund University Publications (LUP) |
| مصطلحات موضوعية: | Geriatrics |
| الوصف: | Background: Various factors modulate circulating testosterone in men, affecting interpretation of testosterone measurements. Purpose: To clarify factors associated with variations in sex hormone concentrations. Data Sources: Systematic literature searches (to July 2019). Study Selection: Prospective cohort studies of community-dwelling men with total testosterone measured using mass spectrometry. Data Extraction: Individual participant data (IPD) (9 studies; n = 21 074) and aggregate data (2 studies; n = 4075). Sociodemographic, lifestyle, and health factors and concentrations of total testosterone, sex hormone–binding globulin (SHBG), luteinizing hormone (LH), dihydrotestosterone, and estradiol were extracted. Data Synthesis: Two-stage random-effects IPD meta-analyses found a nonlinear association of testosterone with age, with negligible change among men aged 17 to 70 years (change per SD increase about the midpoint, -0.27 nmol/L [-7.8 ng/dL] [CI, -0.71 to 0.18 nmol/L {-20.5 to 5.2 ng/dL}]) and decreasing testosterone levels with age for men older than 70 years (-1.55 nmol/L [-44.7 ng/dL] [CI, -2.05 to -1.06 nmol/L {-59.1 to -30.6 ng/dL}]). Testosterone was inversely associated with body mass index (BMI) (change per SD increase, -2.42 nmol/L [-69.7 ng/dL] [CI, -2.70 to -2.13 nmol/L {-77.8 to -61.4 ng/dL}]). Testosterone concentrations were lower for men who were married (mean difference, -0.57 nmol/L [-16.4 ng/dL] [CI, -0.89 to -0.26 nmol/L {-25.6 to -7.5 ng/dL}]); undertook at most 75 minutes of vigorous physical activity per week (-0.51 nmol/L [-14.7 ng/dL] [CI, -0.90 to -0.13 nmol/L {-25.9 to -3.7 ng/dL}]); were former smokers (-0.34 nmol/L [-9.8 ng/dL] [CI, -0.55 to -0.12 nmol/L {-15.9 to -3.5 ng/dL}]); or had hypertension (-0.53 nmol/L [-15.3 ng/dL] [CI, -0.82 to -0.24 nmol/L {-23.6 to -6.9 ng/dL}]), cardiovascular disease (-0.35 nmol/L [-10.1 ng/dL] [CI, -0.55 to -0.15 nmol/L {-15.9 to -4.3 ng/dL}]), cancer (-1.39 nmol/L [-40.1 ng/dL] [CI, -1.79 to -0.99 nmol/L {-51.6 to -28.5 ng/dL}]), or diabetes ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://lup.lub.lu.se/record/ddcc7325-fe03-48bd-856f-1eb77a31f0b1Test; http://dx.doi.org/10.7326/M23-0342Test; scopus:85171806576; pmid:37639720 |
| DOI: | 10.7326/M23-0342 |
| الإتاحة: | https://doi.org/10.7326/M23-0342Test https://lup.lub.lu.se/record/ddcc7325-fe03-48bd-856f-1eb77a31f0b1Test |
| رقم الانضمام: | edsbas.82C172DC |
| قاعدة البيانات: | BASE |
| DOI: | 10.7326/M23-0342 |
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