دورية أكاديمية
Improved Cerebrospinal Fluid-Based Discrimination between Alzheimer's Disease Patients and Controls after Correction for Ventricular Volumes
| العنوان: | Improved Cerebrospinal Fluid-Based Discrimination between Alzheimer's Disease Patients and Controls after Correction for Ventricular Volumes |
|---|---|
| المؤلفون: | van Waalwijk van Doorn, Linda J C, Gispert, Juan D., Kuiperij, H. Bea, Claassen, Jurgen A H R, Arighi, Andrea, Baldeiras, Inês, Blennow, Kaj, Bozzali, Marco, Castelo-Branco, Miguel, Cavedo, Enrica, Emek-Savaş, Derya D., Eren, Erden, Eusebi, Paolo, Farotti, Lucia, Fenoglio, Chiara, Ormaechea, Juan Fortea, Freund-Levi, Yvonne, Frisoni, Giovanni B, Galimberti, Daniela, Genc, Sermin, Greco, Viviana, Hampel, Harald, Herukka, Sanna-Kaisa, Liu, Yawu, Lladó, Albert, Lleó, Alberto, Nobili, Flavio M., Oguz, Kader K., Parnetti, Lucilla, Pereira, João, Picco, Agnese, Pikkarainen, Maria, De Oliveira, Catarina Resende, Saka, Esen, Salvadori, Nicola, Sanchez-Valle, Raquel, Santana, Isabel, Scarpini, Elio, Scheltens, Philip, Soininen, Hilkka, Tarducci, Roberto, Teunissen, Charlotte, Tsolaki, Magda, Urbani, Andrea, Vilaplana, Eduard, Visser, Pieter Jelle, Wallin, Asa K., Yener, Görsev, Molinuevo, José L, Meulenbroek, Olga, Verbeek, Marcel |
| المصدر: | Journal of Alzheimer's Disease; 56(2), pp 543-555 (2017) ; ISSN: 1387-2877 |
| بيانات النشر: | IOS Press |
| سنة النشر: | 2017 |
| المجموعة: | Lund University Publications (LUP) |
| مصطلحات موضوعية: | Neurology, Alzheimer's disease, amyloid biomarkers, cerebrospinal fluid, lateral ventricles, tau protein |
| الوصف: | Cerebrospinal fluid (CSF) biomarkers may support the diagnosis of Alzheimer's disease (AD). We studied if the diagnostic power of AD CSF biomarker concentrations, i.e., Aβ42, total tau (t-tau), and phosphorylated tau (p-tau), is affected by differences in lateral ventricular volume (VV), using CSF biomarker data and magnetic resonance imaging (MRI) scans of 730 subjects, from 13 European Memory Clinics. We developed a Matlab-algorithm for standardized automated segmentation analysis of T1 weighted MRI scans in SPM8 for determining VV, and computed its ratio with total intracranial volume (TIV) as proxy for total CSF volume. The diagnostic power of CSF biomarkers (and their combination), either corrected for VV/TIV ratio or not, was determined by ROC analysis. CSF Aβ42 levels inversely correlated to VV/TIV in the whole study population (Aβ42: r=-0.28; p<0.0001). For CSF t-tau and p-tau, this association only reached statistical significance in the combined MCI and AD group (t-tau: r=-0.15; p-tau: r=-0.13; both p<0.01). Correction for differences in VV/TIV improved the differentiation of AD versus controls based on CSF Aβ42 alone (AUC: 0.75 versus 0.81) or in combination with t-tau (AUC: 0.81 versus 0.91). In conclusion, differences in VV may be an important confounder in interpreting CSF Aβ42 levels. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://lup.lub.lu.se/record/b541c926-4f61-4333-a562-f7ff4e8feb6bTest; http://dx.doi.org/10.3233/JAD-160668Test; scopus:85011320275; pmid:28059783; wos:000395077200011 |
| DOI: | 10.3233/JAD-160668 |
| الإتاحة: | https://doi.org/10.3233/JAD-160668Test https://lup.lub.lu.se/record/b541c926-4f61-4333-a562-f7ff4e8feb6bTest |
| رقم الانضمام: | edsbas.91F2957B |
| قاعدة البيانات: | BASE |
| DOI: | 10.3233/JAD-160668 |
|---|