دورية أكاديمية
The impact of diabetes mellitus on major amputation among patients with chronic limb threatening ischemia undergoing elective endovascular therapy- a nationwide propensity score adjusted analysis
| العنوان: | The impact of diabetes mellitus on major amputation among patients with chronic limb threatening ischemia undergoing elective endovascular therapy- a nationwide propensity score adjusted analysis |
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| المؤلفون: | Lilja, Erika, Gottsäter, Anders, Miftaraj, Mervete, Ekelund, Jan, Eliasson, Björn, Svensson, Ann Marie, Zarrouk, Moncef, Nilsson, Peter, Acosta, Stefan |
| المصدر: | Journal of Diabetes and its Complications; 35(2), no 107675 (2021) ; ISSN: 1056-8727 |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2021 |
| المجموعة: | Lund University Publications (LUP) |
| مصطلحات موضوعية: | Endocrinology and Diabetes, Chronic limb-threatening ischemia, Diabetes mellitus, Endovascular revascularization, Major amputation, Propensity score adjusted analysis |
| الوصف: | Aim: To investigate the risk of major amputation after elective endovascular therapy in patients with chronic limb threatening ischemia (CLTI) comparing patients with and without diabetes mellitus (DM). Methods: In this nationwide cohort study, all patients registered in the Swedish Vascular Register after elective endovascular therapy for CLTI caused by infra-inguinal arterial disease from 2010 to 2014 were included. Among 4578 individuals, 2251 had DM and were registered in the National Diabetes Register between 2009 and 2014. A propensity score adjusted Cox regression analysis was conducted to compare outcomes between groups. Median follow-up was 4.0 and 3.6 years for patients with DM and without DM, respectively. Results: The incidence rates of major amputation and acute myocardial infarction (AMI) were 43% (95% CI 1.23–1.67) and 37% (95% CI 1.13–1.67) higher, respectively, among patients with DM compared to patients without DM. There was no difference in mortality (HR 1.04, 95% CI 0.95–1.14). Conclusions: Patients with DM had a higher risk of major amputation and AMI compared to those without DM after elective endovascular therapy for CLTI. Prevention of DM with CLTI is of utmost importance to reduce the risk of adverse limb and cardiovascular outcomes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://lup.lub.lu.se/record/de390431-d644-4e2a-af05-bb5f9f543f0eTest; http://dx.doi.org/10.1016/j.jdiacomp.2020.107675Test; scopus:85089584825; pmid:32828647 |
| DOI: | 10.1016/j.jdiacomp.2020.107675 |
| الإتاحة: | https://doi.org/10.1016/j.jdiacomp.2020.107675Test https://lup.lub.lu.se/record/de390431-d644-4e2a-af05-bb5f9f543f0eTest |
| رقم الانضمام: | edsbas.2A785398 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jdiacomp.2020.107675 |
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