دورية أكاديمية
An investigation into whether deletions in 9p reflect prognosis in adult precursor B-cell acute lymphoblastic leukemia : a multi-center study of 381 patients
| العنوان: | An investigation into whether deletions in 9p reflect prognosis in adult precursor B-cell acute lymphoblastic leukemia : a multi-center study of 381 patients |
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| المؤلفون: | Nahi, Hareth, Hägglund, Hans, Ahlgren, Thomas, Bernell, Per, Hardling, Mats, Karlsson, Karin, Lazarevic, Vladimir Lj, Linderholm, Mats, Smedmyr, Bengt, Aström, Maria, Hallböök, Helene |
| المصدر: | Haematologica; 93(11), pp 8-1734 (2008) ; ISSN: 1592-8721 |
| بيانات النشر: | Ferrata Storti Foundation |
| سنة النشر: | 2008 |
| المجموعة: | Lund University Publications (LUP) |
| مصطلحات موضوعية: | Hematology, Adolescent, Adult, Aged, Burkitt Lymphoma, Chromosome Mapping, Chromosomes, Human, Pair 1, Pair 22, Pair 9, Genetic Markers, Humans, Karyotyping, Leukocyte Count, Middle Aged, Prognosis, Sequence Deletion, Survival Analysis, Translocation, Genetic, World Health Organization |
| الوصف: | In acute lymphoblastic leukemia, besides age and white cell count at diagnosis, the cytogenetic abnormalities t(9;22)/BCR-ABL and t(4;11)/MLL-AF4 are important prognostic markers and are often included in the treatment stratification of patients with adult acute lymphoblastic leukemia. Deletions in 9p are seen in about 9% of cases of adult acute lymphoblastic leukemia, but their prognostic impact has been controversial. Cytogenetic data from 381 patients diagnosed with B-precursor acute lymphoblastic leukemia were reviewed. Chromosomal analysis was successful in 240 cases. Of these cases, 18 (8%) had abnormalities in 9p and they were compared with patients with normal karyotypes and patients with t(9;22)/BCR-ABL. Patients with abnormalities of chromosome 9 showed significantly shorter overall survival compared with patients with normal karyotypes. In fact, overall survival was similar to that in the poor prognosis t(9;22)/BCR-ABL-positive group. Our data suggest that chromosomal abnormalities involving 9p may have a significant negative impact on survival in adult B-precursor acute lymphoblastic leukemia. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://lup.lub.lu.se/record/a125c62e-84e3-493d-9d24-57fe8de883cdTest; http://dx.doi.org/10.3324/haematol.13227Test; scopus:55549115330; pmid:18728022 |
| DOI: | 10.3324/haematol.13227 |
| الإتاحة: | https://doi.org/10.3324/haematol.13227Test https://lup.lub.lu.se/record/a125c62e-84e3-493d-9d24-57fe8de883cdTest |
| رقم الانضمام: | edsbas.3A4DFA6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3324/haematol.13227 |
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