دورية أكاديمية
The impact of a high-fat diet in mice is dependent on duration and age, and differs between muscles /
| العنوان: | The impact of a high-fat diet in mice is dependent on duration and age, and differs between muscles / |
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| المؤلفون: | Messa, G. A. M., Piasecki, M., Hurst, J., Hill, C., Tallis, J., Degens, H. |
| المصدر: | Journal of experimental biology., London : Company of Biologists Ltd, 2020, vol. 223, iss. 6, art. no. jeb217117, p. 1-15. ; ISSN 0022-0949 ; eISSN 1477-9145 |
| سنة النشر: | 2020 |
| المجموعة: | LSU VL (Lithuanian Sports University Virtual Library) / LSU VB (Lietuvos sporto universitetas virtualią biblioteką) |
| مصطلحات موضوعية: | capillarization, capillary domains, diaphragm, high-fat diet, soleus |
| الوصف: | Prolonged high-fat diets (HFD) can cause intramyocellular lipids (IMCL) accumulation that may negatively affect muscle function. We investigated the duration of a HFD required to instigate these changes, and whether effects are muscle-specific and aggravated in older age. Muscle morphology was determined in the soleus, extensor digitorum longus (EDL) and diaphragm muscles from female CD-1 mice divided into 5 groups: young fed a HFD for 8 weeks (YS-HFD, n=16), young fed a HFD for 16 weeks (YL-HFD, n=28) and young control (Y-CON, n=28). The young animals were 20 weeks old at the end of the experiment. Sixty 70-week-old female CD-1 mice received either a normal diet (O-CON, n=30) or a HFD for 9 weeks (OS-HFD, n=30). Body mass, body mass index and IMCL content increased in old OS-HFD (p≤0.003). In the young mice, this increase was seen in YL-HFD and not YS-HFD (p≤0.006). The soleus and diaphragm fibre cross-sectional area (FCSA) in YL-HFD was larger compared to Y-CON (p≤0.004) while old mice had a larger soleus FCSA compared to CON after only 9 weeks on a HFD (p<0.001). The FCSA of the EDL muscle did not differ significantly between groups. Oxidative capacity of fibres increased in young only, irrespective of HFD duration (p<0.001). High-fat diet-induced morphological changes occur earlier in the old animals when compared to young, and adaptations to HFD are muscle-specific with the EDL being least responsive. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://vb.lsu.lt/object/elaba:50105765/50105765.pdfTest; https://vb.lsu.lt/LSU:ELABAPDB50105765&prefLang=en_USTest |
| الإتاحة: | https://doi.org/10.1242/jeb.217117Test https://vb.lsu.lt/LSU:ELABAPDB50105765&prefLang=en_USTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.9D26C92D |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |