دورية أكاديمية
Factors Affecting the Ovarian Response to a Combined Estradiol-Sulpiride Treatment in Seasonally Anovulatory Mares
| العنوان: | Factors Affecting the Ovarian Response to a Combined Estradiol-Sulpiride Treatment in Seasonally Anovulatory Mares |
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| المؤلفون: | Oberhaus, Erin L., Thompson, Donald L., Pham, Carolyn K. |
| المصدر: | Faculty Publications |
| بيانات النشر: | LSU Digital Commons |
| سنة النشر: | 2017 |
| المجموعة: | LSU Digital Commons (Louisiana State University) |
| مصطلحات موضوعية: | Estradiol cypionate, Mare, Ovulation induction, Seasonal anovulation, Sulpiride |
| الوصف: | © 2016 Elsevier Inc. Twenty-three seasonally anovulatory mares, housed at two separate farms, were treated with 50 mg of estradiol cypionate (ECP) and 3 g of sulpiride in January to study factors that contributed to success of the treatment (response = ovulation within 28 days). Every other day, blood samples and pretreatment secretagogue challenges were used to characterize prolactin, luteinizing hormone (LH), insulin-like growth factor-I, leptin, and insulin concentrations. Ovaries of each mare were scanned via ultrasound regularly until detection of a 32–35 mm follicle, at which time the mare was artificially inseminated. Prolactin was stimulated in all treated mares and was similar (P > .05) in responding and nonresponding mares. Nine mares, all at the same farm (Ben Hur; farm effect, P = .006), responded with preovulatory sized follicles within 20 days of treatment. Five of the 9 were inseminated and 3 conceived. Retrospective analysis revealed that of the mares responding, body condition score (P = .03), body weight (P = .02), plasma concentrations of insulin (P = .01) and leptin (P = .09), and pretreatment response of LH to gonadotropin-releasing hormone (P = .106) were higher in responding than in nonresponding mares. In general, factors that differed and may contribute to whether a given mare responds to this ECP-sulpiride protocol were mainly characteristics pointing toward well-nourished mares. Minor nutritional differences between farms likely played a role in the lack of success on the one farm. Also, the LH response to gonadotropin-releasing hormone prior to treatment may be indicative of the subsequent LH response to ECP-sulpiride and hence the ovarian response. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://digitalcommons.lsu.edu/animalsciences_pubs/1099Test; https://digitalcommons.lsu.edu/context/animalsciences_pubs/article/2098/viewcontent/1099.pdfTest |
| DOI: | 10.1016/j.jevs.2016.12.001 |
| الإتاحة: | https://doi.org/10.1016/j.jevs.2016.12.001Test https://digitalcommons.lsu.edu/animalsciences_pubs/1099Test https://digitalcommons.lsu.edu/context/animalsciences_pubs/article/2098/viewcontent/1099.pdfTest |
| رقم الانضمام: | edsbas.5B2712F5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jevs.2016.12.001 |
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