دورية أكاديمية
Beyond Type 1 Regulatory T Cells: Co-expression of LAG3 and CD49b in IL-10-Producing T Cell Lineages
| العنوان: | Beyond Type 1 Regulatory T Cells: Co-expression of LAG3 and CD49b in IL-10-Producing T Cell Lineages |
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| المؤلفون: | Huang, Weishan, Solouki, Sabrina, Carter, Chavez, Zheng, Song-Guo, August, Avery |
| المصدر: | Faculty Publications |
| بيانات النشر: | LSU Digital Commons |
| سنة النشر: | 2018 |
| المجموعة: | LSU Digital Commons (Louisiana State University) |
| مصطلحات موضوعية: | Foxp3, IL-10, T cell, farmer's lung disease, house dust mite, influenza infection, lung inflammation, parasitic infection |
| الوصف: | Type 1 regulatory CD4 T (Tr1) cells express high levels of the immunosuppressive cytokine IL-10 but not the master transcription factor Foxp3, and can suppress inflammation and promote immune tolerance. In order to identify and obtain viable Tr1 cells for research and clinical applications, co-expression of CD49b and LAG3 has been proposed as a unique surface signature for both human and mouse Tr1 cells. However, recent studies have revealed that this pattern of co-expression is dependent on the stimulating conditions and the differentiation stage of the CD4 T cells. Here, using an IL-10/Foxp3 dual reporter transgenic murine model, we demonstrate that co-expression of CD49b and LAG3 is not restricted to the Foxp3 Tr1 cells, but is also observed in Foxp3 T regulatory (Treg) cells and CD8 T cells that produce IL-10. Our data indicate that IL-10-producing Tr1 cells, Treg cells and CD8 T cells are all capable of co-expressing LAG3 and CD49b following differentiation under IL-10-inducing conditions, and following pathogenic insult or infection in the pulmonary mucosa. Our findings urge caution in the use of LAG3/CD49b co-expression as sole markers to identify Tr1 cells, since it may mark IL-10-producing T cell lineages more broadly, including the Foxp3 Tr1 cells, Foxp3 Treg cells, and CD8 T cells. |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://digitalcommons.lsu.edu/vetmed_pubs/1039Test |
| DOI: | 10.3389/fimmu.2018.02625 |
| الإتاحة: | https://doi.org/10.3389/fimmu.2018.02625Test https://digitalcommons.lsu.edu/vetmed_pubs/1039Test |
| رقم الانضمام: | edsbas.7590738E |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fimmu.2018.02625 |
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