دورية أكاديمية
Empirical treatment against cytomegalovirus and tuberculosis in HIV-infected infants with severe pneumonia: study protocol for a multicenter, open-label randomized controlled clinical trial
| العنوان: | Empirical treatment against cytomegalovirus and tuberculosis in HIV-infected infants with severe pneumonia: study protocol for a multicenter, open-label randomized controlled clinical trial |
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| المؤلفون: | Rojo, Pablo, Moraleda, Cinta, Tagarro, Alfredo, Domínguez-Rodríguez, Sara, Castillo, Lola Madrid, Tato, Luis Manuel Prieto, López, Aranzazu Sancho, Manukyan, Lilit, Marcy, Olivier, Leroy, Valeriane, Nardone, Alessandra, Burger, David, Bassat, Quique, Bates, Matthew, Moh, Raoul, Iroh Tam, Pui-Ying, Mvalo, Tisungane, Magallhaes, Justina, Buck, W. Chris, Sacarlal, Jahit, Musiime, Victor, Chabala, Chishala, Mujuru, Hilda Angela |
| المصدر: | Trials, Vol 23, Issue 1, e531. |
| بيانات النشر: | BioMed Central |
| سنة النشر: | 2022 |
| المجموعة: | LSTM Online Archive (Liverpool School of Tropical Medicine) |
| مصطلحات موضوعية: | WC 20 Research (General), WC 202 Pneumonia (General or not elsewhere classified), WC 503 Acquired immunodeficiency syndrome. HIV infections, WF 200 Tuberculosis (General), WS 430 Infancy |
| الوصف: | Background: Pneumonia is the primary cause of death among HIV-infected children in Africa, with mortality rates as high as 35–40% in infants hospitalized with severe pneumonia. Bacterial pathogens and Pneumocystis jirovecii are well known causes of pneumonia-related death, but other important causes such as cytomegalovirus (CMV) and tuberculosis (TB) remain under-recognized and undertreated. The immune response elicited by CMV may be associated with the risk of developing TB and TB disease progression, and CMV may accelerate disease caused both by HIV and TB. Minimally invasive autopsies confirm that CMV and TB are unrecognized causes of death in children with HIV. CMV and TB may also co-infect the same child. The aim of this study is to compare the impact on 15-day and 1-year mortality of empirical treatment against TB and CMV plus standard of care (SoC) versus SoC in HIV-infected infants with severe pneumonia. Methods: This is a Phase II-III, open-label randomized factorial (2 × 2) clinical trial, conducted in six African countries. The trial has four arms. Infants from 28 to 365 days of age HIV-infected and hospitalized with severe pneumonia will be randomized (1:1:1:1) to (i) SoC, (ii) valganciclovir, (iii) TB-T, and (iv) TB-T plus valganciclovir. The primary endpoint of the study is all-cause mortality, focusing on the short-term (up to 15 days) and long-term (up to 1 year) mortality. Secondary endpoints include repeat hospitalization, duration of oxygen therapy during initial admission, severe and notable adverse events, adverse reactions, CMV and TB prevalence at enrolment, TB incidence, CMV viral load reduction, and evaluation of diagnostic tests such as GeneXpert Ultra on fecal and nasopharyngeal aspirate samples and urine TB-LAM. Discussion: Given the challenges in diagnosing CMV and TB in children and results from previous autopsy studies that show high rates of poly-infection in HIV-infected infants with respiratory disease, this study aims to evaluate a new approach including empirical treatment of ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | https://archive.lstmed.ac.uk/20654/1/13063_2022_Article_6203.pdfTest; Rojo, Pablo, Moraleda, Cinta, Tagarro, Alfredo, Domínguez-Rodríguez, Sara, Castillo, Lola Madrid, Tato, Luis Manuel Prieto, López, Aranzazu Sancho, Manukyan, Lilit, Marcy, Olivier, Leroy, Valeriane, Nardone, Alessandra, Burger, David, Bassat, Quique, Bates, Matthew, Moh, Raoul, Iroh Tam, Pui-Ying orcid:0000-0002-3682-8892 , Mvalo, Tisungane, Magallhaes, Justina, Buck, W. Chris, Sacarlal, Jahit, Musiime, Victor, Chabala, Chishala and Mujuru, Hilda Angela (2022) 'Empirical treatment against cytomegalovirus and tuberculosis in HIV-infected infants with severe pneumonia: study protocol for a multicenter, open-label randomized controlled clinical trial'. Trials, Vol 23, Issue 1, e531. |
| DOI: | 10.1186/s13063-022-06203-1 |
| الإتاحة: | https://doi.org/10.1186/s13063-022-06203-1Test https://archive.lstmed.ac.uk/20654Test/ https://archive.lstmed.ac.uk/20654/1/13063_2022_Article_6203.pdfTest |
| حقوق: | cc_by_4 |
| رقم الانضمام: | edsbas.13807E6B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s13063-022-06203-1 |
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