دورية أكاديمية
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
| العنوان: | Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes |
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| المؤلفون: | Barrett, Jeffrey C, Clayton David, -, Concannon, Patrick, Akolkar, Beena, Cooper, Jason D, Erlich, Henry A, Julier, Cécile, Morahan, Grant, Nerup, Jørn, Nierras, Concepcion, Plagnol, Vincent, Pociot, Flemming, Schuilenburg, Helen, Smyth, Deborah J, Stevens, Helen, Todd, John A, Walker, Neil M, Rich, Stephen S, Veličkienė, Džilda |
| المصدر: | Nature Genetics, New York : Nature Publishing Group, 2009, vol. 41, iss. 6, p. 703-707 ; ISSN 1061-4036 |
| سنة النشر: | 2009 |
| المجموعة: | LSRC VL (Lithuanian Social Research Centre Virtual Library) / LSTC VB (Lietuvos socialinių tyrimų centras virtualią biblioteką) |
| مصطلحات موضوعية: | Diabetes mellitus, type 1, Genetics, Chromosomes, human, pair 1, pair 17, pair 2, Polymorphism, single nucleotide, Protein tyrosine phosphatase, non-receptor type 22, Risk assessment, Genome-wide association study, Meta-analysis as topic, info:eu-repo/classification/udc/616.379-008.64 |
| الوصف: | Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D, combined in a meta-analysis with two previously published studies. The total sample set included 7,514 cases and 9,045 reference samples. Forty-one distinct genomic locations provided evidence for association with T1D in the meta-analysis (P < 10(-6)). After excluding previously reported associations, we further tested 27 regions in an independent set of 4,267 cases, 4,463 controls and 2,319 affected sib-pair (ASP) families. Of these, 18 regions were replicated (P < 0.01; overall P < 5 × 10(-8)) and 4 additional regions provided nominal evidence of replication (P < 0.05). The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | http://lsmu.lvb.lt/LSMU:ELABAPDB5581649&prefLang=en_USTest |
| الإتاحة: | https://doi.org/10.1038/ng.381Test http://lsmu.lvb.lt/LSMU:ELABAPDB5581649&prefLang=en_USTest |
| رقم الانضمام: | edsbas.FF4EE93F |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |