التفاصيل البيبلوغرافية
| العنوان: |
Potential biomarkers of type 2 airway inflammation and bronchial epithelial injury in allergic asthma |
| المؤلفون: |
Kalinauskaitė-Žukauskė, Virginija, Januškevičius, Andrius, Janulaitytė, Ieva, Malakauskas, Kęstutis |
| المصدر: |
Health for all: Science and innovation week 2019 : International doctoral and resident students conference: Science for health : abstract book : Kaunas, Lithuania, 8-12 April, 2019 / Edited by Elvinas Monstavičius, Alvita Vilkevičiūtė, Kaunas : Council of LSMU Doctoral Students, 2019, p. 44-45 ; ISSN 2669-0314 |
| سنة النشر: |
2019 |
| المجموعة: |
LSRC VL (Lithuanian Social Research Centre Virtual Library) / LSTC VB (Lietuvos socialinių tyrimų centras virtualią biblioteką) |
| مصطلحات موضوعية: |
Asthma, pathology, Respiratory mucosa, injuries, Biomarkers, blood, info:eu-repo/classification/udc/616.248 |
| الوصف: |
Introduction Type-2 inflammation and bronchial epithelial injury play a pivotal role in the pathogenesis of allergic asthma (AA). Cytokines are crucial in orchestrating, perpetuating and amplifying the airway inflammatory response. Interleukin (IL)-4, IL-13 is deeply involved in immunoglobulin E synthesis, eosinophil activation, mucus secretion and airways remodelling, IL-25, IL-33, IL-8 appear to be sensitive to epithelial injury. There is a lack of data about these cytokines changes after contact with the inhaled allergen. Aim To investigate serum levels of cytokines IL-4, IL-8, IL-13, IL-25, IL-33 in acute AA. Methods We examined 16 patients: 8 steroid-free, stable, sensitized to Dermatophagoides pteronyssinus patients with AA and 8 healthy, non-atopic subjects (HS). Peripheral blood eosinophils were isolated using centrifugation and magnetic separation. Bronchial allergen challenge was performed using inhaled D. pteronyssinus (Diater, Spain) via a pressure dosimeter (ProvoX, Ganshorn, Germany). Cytokines levels in serum were measured by ELISA before allergen challenge (V1) and after 24 hours (V2). Results At the baseline (V1) patients from the AA group had significant higher eosinophil count (0.39±0.21 vs 0.17±0.10 x1012/l), serum levels of IL-4 (46.7±7.3 vs 11.3±2.2 pg/ml), IL-13 (889.1±177.5 vs 218.5±67.8 pg/ml) compared to HS (p<0.05). After allergen challenge test eosinophil count in AA significantly increased to 0.46±0.13 x1012/l; IL-4 - 62.8±7.3, IL-8 - 48.8±9.0, IL-13 - 1121.0±218.4, IL-25 - 63.5±13.1 pg/ml (p<0.05) without significant changes in HS. |
| نوع الوثيقة: |
conference object |
| اللغة: |
English |
| العلاقة: |
http://lsmu.lvb.lt/LSMU:ELABAPDB36308846&prefLang=en_USTest |
| الإتاحة: |
http://lsmu.lvb.lt/LSMU:ELABAPDB36308846&prefLang=en_USTest |
| رقم الانضمام: |
edsbas.576A23B3 |
| قاعدة البيانات: |
BASE |
