دورية أكاديمية
Vaccinations and Immunization Status in Pediatric Inflammatory Bowel Disease: A Multicenter Study From the Pediatric IBD Porto Group of the ESPGHAN
| العنوان: | Vaccinations and Immunization Status in Pediatric Inflammatory Bowel Disease: A Multicenter Study From the Pediatric IBD Porto Group of the ESPGHAN |
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| المؤلفون: | Martinelli, Massimo, Giugliano, Francesca Paola, Strisciuglio, Caterina, Urbonas, Vaidotas, Serban, Daniela Elena, Banaszkiewicz, Aleksandra, Assa, Amit, Hojsak, Iva, Lerchova, Tereza, Navas-López, Víctor Manuel, Romano, Claudio, Sladek, Małgorzata, Veres, Gabor, Aloi, Marina, Kucinskiene, Ruta, Miele, Erasmo |
| المصدر: | Inflammatory bowel diseases, Cary : Oxford University Press, 2020, vol. 26, no. 9, p. 1407-1414 ; ISSN 1078-0998 ; eISSN 1536-4844 |
| سنة النشر: | 2020 |
| المجموعة: | LSRC VL (Lithuanian Social Research Centre Virtual Library) / LSTC VB (Lietuvos socialinių tyrimų centras virtualią biblioteką) |
| مصطلحات موضوعية: | inflammatory bowel disease, pediatrics, vaccinations |
| الوصف: | BACKGROUND: Vaccine-preventable diseases and opportunistic infections in pediatric inflammatory bowel disease (IBD) are increasingly recognized issues. The aims of this study were to evaluate vaccinations, immunization status, and consequent therapeutic management in children with IBD and to analyze the differences among patients diagnosed before (Group 1) and after June 2012 (Group 2). METHODS: This was a multicenter, retrospective cohort investigation. Between July 2016 and July 2017, 430 children with IBD were enrolled in 13 centers. Diagnosis, therapeutic history, vaccinations, and immunization status screening at diagnosis and at immunosuppressant (IM)/biologic initiation and reasons for incomplete immunization were retrieved. RESULTS: Vaccination rates at diagnosis were unsatisfactory for measles, mumps, and rubella (89.3%), Haemophilus influenzae (81.9%), meningococcus C (23.5%), chickenpox (18.4%), pneumococcus (18.6%), papillomavirus (5.9%), and rotavirus (1.9%). Complete immunization was recorded in 38/430 (8.8%) children, but specific vaccines were recommended in 79/430 patients (18.6%), without differences between the 2 groups. At IM start, 22% of children were tested for Epstein-Barr virus (EBV) status, with 96.2% of EBV-naïve patients starting azathioprine, without differences between Groups 1 and 2. Screening for latent tuberculosis (TB) before start of biologics was performed in 175/190 (92.1%), with up to 9 different screening strategies and numerous inconsistencies. CONCLUSIONS: We demonstrated a poor immunization status at diagnosis in children with IBD, which was not followed by proper vaccination catch-up. EBV status before IM initiation and latent TB before biologics were not adequately assessed. Thus, the overall impact of the current guidelines seems unsatisfactory. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | http://lsmu.lvb.lt/LSMU:ELABAPDB43173853&prefLang=en_USTest |
| الإتاحة: | https://doi.org/10.1093/ibd/izz264Test http://lsmu.lvb.lt/LSMU:ELABAPDB43173853&prefLang=en_USTest |
| رقم الانضمام: | edsbas.4E0F3AD9 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |