دورية أكاديمية
Towards clinical breakpoints for non-tuberculous mycobacteria-Determination of epidemiological cut off values for the Mycobacterium avium complex and Mycobacterium abscessus using broth microdilution
| العنوان: | Towards clinical breakpoints for non-tuberculous mycobacteria-Determination of epidemiological cut off values for the Mycobacterium avium complex and Mycobacterium abscessus using broth microdilution |
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| المؤلفون: | Froberg, Gabrielle, Maurer, Florian P., Chryssanthou, Erja, Fernstrom, Louise, Benmansour, Hanaa, Boarbi, Samira, Mengshoel, Anne Torunn, Keller, Peter Michael, Viveiros, Miguel, Machado, Diana, Fitzgibbon, Margaret M., Mok, Simone, Werngren, Jim, Cirillo, Daniela Maria, Alcaide, Fernando, Hyyrylainen, Hanne-Leena, Aubry, Alexandra, Andres, Sonke, Nadarajan, Darshaalini, Svensson, Erik, Turnidge, John, Giske, Christian G., Kahlmeter, Gunnar, Cambau, Emmanuelle, van Ingen, Jakko, Schön, Thomas |
| بيانات النشر: | Linköpings universitet, Avdelningen för inflammation och infektion Linköpings universitet, Medicinska fakulteten Region Östergötland, Infektionskliniken i Östergötland Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden Res Ctr Borstel, Germany; Univ Med Ctr Hamburg Eppendorf, Germany Lycksele Hosp, Sweden Univ Paris Cite, France Sciensano, Belgium Norwegian Inst Publ Hlth, Norway Univ Bern, Switzerland Univ Nova Lisboa, Portugal St James Hosp, Ireland; Trinity Coll Dublin, Ireland Publ Hlth Agcy Sweden, Sweden IRCCS San Raffaele Sci Inst, Italy Univ Barcelona, Spain Finnish Inst Hlth & Welf, Finland Sorbonne Univ, France Res Ctr Borstel, Germany Statens Serum Inst, Denmark Univ Adelaide, Australia Cent Hosp Vaxjo, Sweden Radboud Univ Nijmegen, Netherlands Kalmar Cty Hosp, Sweden ELSEVIER SCI LTD |
| سنة النشر: | 2023 |
| المجموعة: | Linköping University Electronic Press (LiU E-Press) |
| مصطلحات موضوعية: | Broth microdilution, Drug susceptibility testing, ECOFF, Mycobacterium, Mycobacterium abscessus, Mycobacterium avium, Non-tuberculous mycobacteria, Infectious Medicine, Infektionsmedicin |
| الوصف: | Objective: For non-tuberculous mycobacteria (NTM), minimum inhibitory concentration (MIC) distri-butions of wild-type isolates have not been systematically evaluated despite their importance for establishing antimicrobial susceptibility testing (AST) breakpoints.Methods: We gathered MIC distributions for drugs used against the Mycobacterium avium complex (MAC) and Mycobacterium abscessus (MAB) obtained by commercial broth microdilution (SLOMYCOI and RAPMYCOI) from 12 laboratories. Epidemiological cut-off values (ECOFFs) and tentative ECOFFs (TEC-OFFs) were determined by EUCAST methodology including quality control (QC) strains.Results: The clarithromycin ECOFF was 16 mg/L for M. avium (n = 1271) whereas TECOFFs were 8 mg/L for M. intracellulare (n = 415) and 1 mg/L for MAB (n = 1014) confirmed by analysing MAB subspecies without inducible macrolide resistance (n = 235). For amikacin, the ECOFFs were 64 mg/L for MAC and MAB. For moxifloxacin, the WT spanned >8 mg/L for both MAC and MAB. For linezolid, the ECOFF and TECOFF were 64 mg/L for M. avium and M. intracellulare, respectively. Current CLSI breakpoints for amikacin (16 mg/L), moxifloxacin (1 mg/L) and linezolid (8 mg/L) divided the corresponding WT dis-tributions. For QC M. avium and M. peregrinum, >= 95% of MIC values were well within recommended QC ranges.Conclusion: As a first step towards clinical breakpoints for NTM, (T)ECOFFs were defined for several antimicrobials against MAC and MAB. Broad wild-type MIC distributions indicate a need for further method refinement which is now under development within the EUCAST subcommittee for anti-mycobacterial drug susceptibility testing. In addition, we showed that several CLSI NTM breakpoints are not consistent in relation to the (T)ECOFFs. Gabrielle Froeuroberg, Clin Microbiol Infect 2023;29:758 (c) 2023 The Author(s). Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases. This is an open access article under the CC BY license (http://creativecommonsTest. ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | Clinical Microbiology and Infection, 1198-743X, 2023, 29:6, s. 758-764; http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-196879Test; PMID 36813087; ISI:001010999300001 |
| DOI: | 10.1016/j.cmi.2023.02.007 |
| الإتاحة: | https://doi.org/10.1016/j.cmi.2023.02.007Test http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-196879Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.9EEE86EB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.cmi.2023.02.007 |
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