دورية أكاديمية
Impact of lymphadenectomy and lymphoedema on health-related quality of life 1 year after surgery for endometrial cancer : A prospective longitudinal multicentre study
| العنوان: | Impact of lymphadenectomy and lymphoedema on health-related quality of life 1 year after surgery for endometrial cancer : A prospective longitudinal multicentre study |
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| المؤلفون: | Wedin, Madelene, Stålberg, K., Marcickiewicz, J., Ahlner, Eva, Åkesson, Å., Lindahl, Gabriel, Borendal Wodlin, Ninnie, Kjölhede, Preben |
| بيانات النشر: | Linköpings universitet, Avdelningen för barns och kvinnors hälsa Linköpings universitet, Medicinska fakulteten Region Östergötland, Kvinnokliniken US Linköpings universitet, Avdelningen för kirurgi, ortopedi och onkologi Region Östergötland, Onkologiska kliniken US Uppsala Univ, Sweden Varberg Hosp, Sweden Univ Gothenburg, Sweden Wiley |
| سنة النشر: | 2022 |
| المجموعة: | Linköping University Electronic Press (LiU E-Press) |
| مصطلحات موضوعية: | Endometrial cancer, health-related quality-of-life, lower limb, lymphadenectomy, lymphoedema, Obstetrics, Gynecology and Reproductive Medicine, Reproduktionsmedicin och gynekologi |
| الوصف: | Objective To assess the impact of lymphadenectomy and lymphoedema of the lower limbs (LLL) on health-related quality of life (HRQoL) 1 year after surgery for endometrial cancer (EC). Design Prospective longitudinal cohort multicentre study. Setting Departments of obstetrics and gynaecology at four university hospitals, six central hospitals and four county hospitals in Sweden. Population Two-hundred-and-thirty-five women with early stage EC were included; 116 with high-risk EC underwent surgery including lymphadenectomy (+LA), and 119 with low-risk EC had surgery without lymphadenectomy (-LA). Methods The generic SF-36 and EQ-5D-3L and the lymphoedema-specific LYMQOL questionnaire were used to assess HRQoL. LLL was assessed by systematic circumferential measurements of the legs enabling volume estimation, clinical evaluation and patient-reported perception of leg swelling. All assessments were carried out on four occasions; preoperatively, and 4-6 weeks, 6 months and 1 year postoperatively. Main outcome measure HRQoL scores. Results No significant differences were seen in HRQoL between the +LA and -LA groups 1 year postoperatively. Irrespective of method of determining LLL, women with LLL were significantly more affected in the LYMQOL domains Function, Appearance/body image and Physical symptoms, but not in the domain Emotion/mood, than women without LLL. No such differences were seen in the generic HRQoL or in the LYMQOL global score between the groups with and without LLL. Conclusions Lymphadenectomy did not seem to affect generic HRQoL adversely. Irrespective of the method of measuring, LLL affected the lymphoedema-specific HRQoL negatively, mainly in physical domains, but had no impact on the generic HRQoL. Tweetable abstract Lymphoedema has impact on lymphoedema-specific, but not on generic, HRQoL, 1 year after surgery for EC. ; Funding Agencies|Swedish Cancer Society (Cancerfonden)Swedish Cancer Society [CAN2013/620]; Medical Research Council of Southeast SwedenUK Research & Innovation (UKRI)Medical ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | British Journal of Obstetrics and Gynecology, 1470-0328, 2022, 129:3, s. 450-460; orcid:0000-0002-3730-7722; orcid:0000-0001-5702-4116; http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-179416Test; PMID 34437763; ISI:000693931500001 |
| DOI: | 10.1111/1471-0528.16870 |
| الإتاحة: | https://doi.org/10.1111/1471-0528.16870Test http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-179416Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.B6426BAF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/1471-0528.16870 |
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