دورية أكاديمية
Whole-body MRI surveillance in TP53 carriers is perceived as beneficial with no increase in cancer worry regardless of previous cancer: Data from the Swedish TP53 Study
| العنوان: | Whole-body MRI surveillance in TP53 carriers is perceived as beneficial with no increase in cancer worry regardless of previous cancer: Data from the Swedish TP53 Study |
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| المؤلفون: | Omran, Meis, Johansson, Hemming, Lundgren, Claudia, Silander, Gustav, Stenmark-Askmalm, Marie, Loman, Niklas, Baan, Annika, Adra, Jamila, Kuchinskaya, Ekaterina, Blomqvist, Lennart, Tham, Emma, Bajalica-Lagercrantz, Svetlana, Brandberg, Yvonne |
| بيانات النشر: | Linköpings universitet, Avdelningen för cellbiologi Linköpings universitet, Medicinska fakulteten Region Östergötland, Klinisk genetik Karolinska Inst, Sweden; Karolinska Univ Hosp Solna, Sweden Karolinska Inst, Sweden Uppsala Univ Hosp, Sweden Umea Univ, Sweden Skane Univ Hosp, Sweden Lund Univ, Sweden; Skane Univ Hosp, Sweden Sahlgrens Univ Hosp, Sweden Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden Karolinska Inst, Sweden; Karolinska Univ Hosp Solna, Sweden; Karolinska Univ Hosp, Sweden WILEY |
| سنة النشر: | 2023 |
| المجموعة: | Linköping University Electronic Press (LiU E-Press) |
| مصطلحات موضوعية: | cancer worry scale, health-related quality-of-life, hereditary cancer, heritable TP53-related cancer syndromes, Li-Fraumeni syndrome, surveillance, Cancer and Oncology, Cancer och onkologi |
| الوصف: | BackgroundTo evaluate the psychosocial consequences of surveillance with whole-body MRI (WB-MRI) in individuals with the heritable TP53-related cancer (hTP53rc) syndrome, also known as the Li-Fraumeni syndrome, with regard to cancer worry, perceived benefits and risks to surveillance and overall health. Patients and methodsSince 2016, the national Swedish TP53 Study (SWEP53) has offered surveillance with WB-MRI to all individuals with hTP53rc syndrome. Seventy-five individuals have been included in the study. Sixty consecutive participants fulfilled a base-line evaluation as well as an evaluation after 1 year with structured questionnaires including the Cancer Worry Scale (CWS), perceived benefits and risks of surveillance, and the 36-item Short Form Survey (SF-36). Individuals with or without previous personal cancer diagnosis were enrolled and results at baseline and after 1 year of surveillance were compared. For SF-36, a comparison with the normal population was also made. ResultsParticipants with previous cancer tend to worry more about cancer, but both individuals with and without cancer had a positive attitude toward surveillance with no differences regarding perceived benefits and barriers to surveillance. Participants with a previous cancer scored significantly lower on some of the SF-36 subscales, but between-group differences were found only for social functioning after 1 year. ConclusionsSurveillance with WB-MRI is feasible from a psychosocial point of view both among TP53 carriers with as well as without a previous history of cancer and does not increase cancer worry in any of the groups. Plain language summary Individuals with heritable TP53-related cancer syndrome (also known as the Li-Fraumeni syndrome) have a high lifetime risk of developing cancer.These TP53 carriers are offered surveillance with whole-body MRI to detect cancer early. There are few reports of the psychosocial impact of surveillance.In this study, we wanted to evaluate cancer worry, benefits and barriers to participation, and ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | Cancer, 0008-543X, 2023, 129:6, s. 946-955; http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-191367Test; PMID 36601958; ISI:000907544400001 |
| DOI: | 10.1002/cncr.34631 |
| الإتاحة: | https://doi.org/10.1002/cncr.34631Test http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-191367Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.F1CF4DF5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/cncr.34631 |
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