دورية أكاديمية
High prevalence of carpal tunnel syndrome in individuals with rare nerve growth factor-beta mutation
| العنوان: | High prevalence of carpal tunnel syndrome in individuals with rare nerve growth factor-beta mutation |
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| المؤلفون: | Ridderström, Mikael, Svantesson, Mats, Thorell, Oumie, Magounakis, Theofilos, Minde, Jan, Olausson, Håkan, Nagi, Saad |
| بيانات النشر: | Linköpings universitet, Centrum för social och affektiv neurovetenskap Linköpings universitet, Medicinska fakulteten Region Östergötland, Neurofysiologiska kliniken US Gällivare Hospital, Gällivare, Sweden Western Sydney University, Sydney, Australia Piteå Älvdals Hospital, Piteå, Sweden Gällivare Hospital, Gällivare, Sweden; Umeå University Hospital, Umeå, Sweden United Kingdom |
| سنة النشر: | 2020 |
| المجموعة: | Linköping University Electronic Press (LiU E-Press) |
| مصطلحات موضوعية: | Carpal tunnel syndrome, hereditary sensory and autonomic neuropathy type V, nerve conduction, nerve growth factor, ultrasonography, Neurology, Neurologi |
| الوصف: | In Sweden, a large family with a point mutation in the nerve growth factor-beta gene has previously been identified. The carriers of this mutation have reduced small-fiber density and selective deficits in deep pain and temperature modalities. The clinical findings in this population are described as hereditary sensory and autonomic neuropathy type V. The purpose of the current study was to investigate the prevalence of carpal tunnel syndrome in hereditary sensory and autonomic neuropathy type V based on clinical examinations and electrophysiological measurements. Further, the cross-sectional area of the median nerve at the carpal tunnel inlet was measured with ultrasonography. Out of 52 known individuals heterozygous for the nerve growth factor-beta mutation in Sweden, 23 participated in the current study (12 males, 11 females; mean age, 55 years; range, 25 to 86 years). All participants answered a health questionnaire and underwent clinical examination followed by median nerve conduction study in a case-control design, and measurement of the nerve cross-sectional area with ultrasonography. The diagnosis of carpal tunnel syndrome was made based on consensus criteria using patient history and nerve conduction study. The prevalence of carpal tunnel syndrome in the hereditary sensory and autonomic neuropathy group was 35% (95% CI 19-55%) or 52% (95% CI 37-74%) depending on whether those individuals who had classic symptoms of carpal tunnel syndrome but negative nerve conduction studies were included or not. Those who had a high likelihood of carpal tunnel syndrome based on classic/probable patient history with positive nerve conduction study had a significantly larger median nerve cross-sectional area than those who had an unlikely patient history with negative nerve conduction study. The prevalence of carpal tunnel syndrome was 10 to 25 times higher in individuals heterozygous for the nerve growth factor-beta mutation than the general Swedish population. Further studies are needed to better understand the ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | Brain Communications, 2020, 2:2; orcid:0000-0001-8773-8232; http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-167164Test; ISI:000639431800026 |
| DOI: | 10.1093/braincomms/fcaa085 |
| الإتاحة: | https://doi.org/10.1093/braincomms/fcaa085Test http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-167164Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.CC79002C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/braincomms/fcaa085 |
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