دورية أكاديمية
Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals
| العنوان: | Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals |
|---|---|
| المؤلفون: | Xue, Pei, Merikanto, Ilona, Chung, Frances, Morin, Charles M., Espie, Colin, Bjorvatn, Bjorn, Cedernaes, Jonathan, Landtblom, Anne-Marie, Penzel, Thomas, De Gennaro, Luigi, Holzinger, Brigitte, Matsui, Kentaro, Hrubos-Strom, Harald, Korman, Maria, Leger, Damien, Mota-Rolim, Sergio, Bolstad, Courtney J., Nadorff, Michael, Plazzi, Giuseppe, Reis, Catia, Chan, Rachel Ngan Yin, Wing, Yun Kwok, Yordanova, Juliana, Bjelajac, Adrijana Koscec, Inoue, Yuichi, Partinen, Markku, Dauvilliers, Yves, Benedict, Christian |
| بيانات النشر: | Linköpings universitet, Avdelningen för neurobiologi Linköpings universitet, Medicinska fakulteten Uppsala Univ, Sweden Univ Helsinki, Finland Univ Toronto, Canada Univ Laval, Canada Univ Oxford, England Univ Bergen, Norway; Haukeland Hosp, Norway Uppsala Univ, Sweden; Uppsala Univ, Sweden; Northwestern Univ, IL USA Charite, Germany Sapienza Univ Rome, Italy; IRCCS Fdn Santa Lucia, Italy Med Univ Vienna, Austria Natl Ctr Hosp, Japan Akershus Univ Hosp, Norway; Univ Oslo, Norway Ariel Univ, Israel Hop Hotel Dieu Paris, France; Univ Paris, France Onofre Lopes Univ Hosp, Brazil; Univ Fed Rio Grande do Norte, Brazil Mississippi State Univ, MS USA IRCCS Ist Sci Neurol Bologna, Italy; Univ Modena & Reggio Emilia, Italy Univ Catolica Portuguesa, Portugal; Univ Lisbon, Portugal; Univ Lisbon, Portugal Chinese Univ Hong Kong, Peoples R China Bulgarian Acad Sci, Bulgaria Inst Med Res & Occupat Hlth, Croatia Tokyo Med Univ, Japan; Japan Somnol Ctr, Japan Univ Helsinki, Finland; Terveystalo Healthcare Serv, Finland Univ Montpellier, France SPRINGERNATURE |
| سنة النشر: | 2023 |
| المجموعة: | Linköping University Electronic Press (LiU E-Press) |
| مصطلحات موضوعية: | Gerontology, specialising in Medical and Health Sciences, Gerontologi, medicinsk/hälsovetenskaplig inriktning |
| الوصف: | Short nighttime sleep duration impairs the immune response to virus vaccination, and long nighttime sleep duration is associated with poor health status. Thus, we hypothesized that short (<6 h) and long (>9 h) nighttime sleepers have a higher post-COVID risk than normal nighttime sleepers, despite two doses of mRNA vaccine (which has previously been linked to lower odds of long-lasting COVID-19 symptoms). Post-COVID was defined as experiencing at least one core COVID-19 symptom for at least three months (e.g., shortness of breath). Multivariate logistic regression adjusting for age, sex, BMI, and other factors showed in 9717 respondents (age span 18-99) that two mRNA vaccinations lowered the risk of suffering from post-COVID by about 21% (p < 0.001). When restricting the analysis to double-vaccinated respondents (n = 5918), short and long sleepers exhibited a greater post-COVID risk than normal sleepers (adjusted OR [95%-CI], 1.56 [1.29, 1.88] and 1.87 [1.32, 2.66], respectively). Among respondents with persistent sleep duration patterns during the pandemic compared to before the pandemic, short but not long sleep duration was significantly associated with the post-COVID risk (adjusted OR [95%-CI], 1.59 [1.24, 2.03] and 1.18 [0.70, 1.97], respectively). No significant association between sleep duration and post-COVID symptoms was observed in those reporting positive SARS-CoV-2 test results (n = 538). Our findings suggest that two mRNA vaccinations against SARS-CoV-2 are associated with a lower post-COVID risk. However, this protection may be less pronounced among those sleeping less than 6 h per night. Our findings warrant replication in cohorts with individuals with confirmed SARS-CoV-2 infection. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | Translational Psychiatry, 2023, 13:1; http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-192458Test; PMID 36726008; ISI:000923536600001 |
| DOI: | 10.1038/s41398-023-02334-4 |
| الإتاحة: | https://doi.org/10.1038/s41398-023-02334-4Test http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-192458Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.5DA7BACC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41398-023-02334-4 |
|---|