دورية أكاديمية
Intraductal papillary neoplasms of the bile duct: a European retrospective multicenter observational study (EUR-IPNB study)
| العنوان: | Intraductal papillary neoplasms of the bile duct: a European retrospective multicenter observational study (EUR-IPNB study) |
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| المؤلفون: | Lluis, Nuria, Serradilla-Martin, Mario, Achalandabaso, Mar, Jehaes, Francois, Dasari, Bobby V. M., Mambrilla-Herrero, Sara, Sparrelid, Ernesto, Balakrishnan, Anita, Hoogwater, Frederik J. H., Amaral, Maria J., Andersson, Bodil, Berrevoet, Frederik, Doussot, Alexandre, Lopez-Lopez, Victor, Alsammani, Mohammedsuror, Detry, Olivier, Domingo-del Pozo, Carlos, Machairas, Nikolaos, Pekli, Damjan, Alcazar-Lopez, Candido F., Asbun, Horacio, Björnsson, Bergthor, Christophides, Thalis, Diez-Caballero, Alberto, Francart, David, Noel, Colin B., Sousa-Silva, Donzilia, Toledo-Martinez, Enrique, Tzimas, George N., Yaqub, Sheraz, Cauchy, Francois, Prieto-Calvo, Mikel, DSouza, Melroy A., Spiers, Harry V. M., van den Heuvel, Marius C., Charco, Ramon, Lesurtel, Mickael, Ramia, Jose M. |
| بيانات النشر: | Linköpings universitet, Avdelningen för kirurgi, ortopedi och onkologi Linköpings universitet, Medicinska fakulteten Region Östergötland, Kirurgiska kliniken US Miami Canc Inst, FL 33176 USA Miguel Servet Univ Hosp, Spain Hosp Univ Vall dHebron, Spain Univ Paris Cite, France Queen Elizabeth Hosp, England Cruces Univ Hosp, Spain Karolinska Inst, Sweden Cambridge Univ Hosp NHS Fdn Trust, England; Univ Cambridge, England Univ Groningen, Netherlands Ctr Hosp & Univ Coimbra, Portugal; Univ Coimbra, Portugal Lund Univ, Sweden; Skane Univ Hosp, Sweden Univ Hosp Gent, Belgium CHU Besancon, France Clin & Univ Hosp Virgen La Arrixaca, Spain Univ Witwatersrand, South Africa Univ Liege, Belgium Hosp Doctor Peset, Spain Natl & Kapodistrian Univ Athens, Greece Semmelweis Univ, Hungary Dr Balmis Gen Univ Hosp, Spain; Alicante Inst Hlth & Biomed Res ISABIAL, Spain Nicosia Gen Hosp, Cyprus Quirurg Cirujanos Asociados, Spain CHC Grp Sante, Belgium Univ Free State, South Africa CHU Porto, Portugal Hosp Univ Marques de Valdecilla, Spain Hygeia Hosp, Greece Oslo Univ Hosp, Norway; Univ Oslo, Norway Dr Balmis Gen Univ Hosp, Spain; Alicante Inst Hlth & Biomed Res ISABIAL, Spain; Miguel Hernandez Univ, Spain LIPPINCOTT WILLIAMS & WILKINS |
| سنة النشر: | 2023 |
| المجموعة: | Linköping University Electronic Press (LiU E-Press) |
| مصطلحات موضوعية: | bile duct neoplasms, intraductal precursor lesion, pancreas, surgical resection, textbook outcome, Surgery, Kirurgi |
| الوصف: | Background/Purpose:Intraductal papillary neoplasm of the bile duct (IPNB) is a rare disease in Western countries. The main aim of this study was to characterize current surgical strategies and outcomes in the mainly European participating centers. Methods:A multi-institutional retrospective series of patients with a diagnosis of IPNB undergoing surgery between 1 January 2010 and 31 December 2020 was gathered under the auspices of the European-African Hepato-Pancreato-Biliary Association. The textbook outcome (TO) was defined as a non-prolonged length of hospital stay plus the absence of any Clavien-Dindo grade at least III complications, readmission, or mortality within 90 postoperative days. Results:A total of 28 centers contributed 85 patients who underwent surgery for IPNB. The median age was 66 years (55-72), 49.4% were women, and 87.1% were Caucasian. Open surgery was performed in 72 patients (84.7%) and laparoscopic in 13 (15.3%). TO was achieved in 54.1% of patients, reaching 63.8% after liver resection and 32.0% after pancreas resection. Median overall survival was 5.72 years, with 5-year overall survival of 63% (95% CI: 50-82). Overall survival was better in patients with Charlson comorbidity score 4 or less versus more than 4 (P=0.016), intrahepatic versus extrahepatic tumor (P=0.027), single versus multiple tumors (P=0.007), those who underwent hepatic versus pancreatic resection (P=0.017), or achieved versus failed TO (P=0.029). Multivariable Cox regression analysis showed that not achieving TO (HR: 4.20; 95% CI: 1.11-15.94; P=0.03) was an independent prognostic factor of poor overall survival. Conclusions:Patients undergoing liver resection for IPNB were more likely to achieve a TO outcome than those requiring a pancreatic resection. Comorbidity, tumor location, and tumor multiplicity influenced overall survival. TO was an independent prognostic factor of overall survival. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | International Journal of Surgery, 1743-9191, 2023, 109:4, s. 760-771; orcid:0000-0001-9704-1260; http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-196563Test; PMID 36917142; ISI:000999427500013 |
| DOI: | 10.1097/JS9.0000000000000280 |
| الإتاحة: | https://doi.org/10.1097/JS9.0000000000000280Test http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-196563Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.6FF8CDE7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1097/JS9.0000000000000280 |
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