دورية أكاديمية
Unexpected Fat Distribution in Adolescents With Narcolepsy
| العنوان: | Unexpected Fat Distribution in Adolescents With Narcolepsy |
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| المؤلفون: | Morales Drissi, Natasha, Romu, Thobias, Landtblom, Anne-Marie, Szakacs, Attila, Hallbook, Tove, Darin, Niklas, Borga, Magnus, Dahlqvist Leinhard, Olof, Engström, Maria |
| بيانات النشر: | Linköpings universitet, Avdelningen för radiologiska vetenskaper Linköpings universitet, Medicinska fakulteten Linköpings universitet, Institutionen för medicinsk teknik Linköpings universitet, Tekniska fakulteten Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV Linköpings universitet, Avdelningen för neuro- och inflammationsvetenskap Region Östergötland, Neurologiska kliniken i Linköping Linköpings universitet, Avdelningen för medicinsk teknik Region Östergötland, Radiofysikavdelningen US AMRA Med AB, Linkoping, Sweden Uppsala Univ, Sweden Univ Gothenburg, Sweden FRONTIERS MEDIA SA |
| سنة النشر: | 2018 |
| المجموعة: | Linköping University Electronic Press (LiU E-Press) |
| مصطلحات موضوعية: | orexin, hypocretin, brown adipose tissue, visceral adipose tissue, subcutaneous adipose tissue, BMI, magnetic resonance imaging (MRI), obesity, Endocrinology and Diabetes, Endokrinologi och diabetes |
| الوصف: | Narcolepsy type 1 is a chronic sleep disorder with significantly higher BMI reported in more than 50% of adolescent patients, putting them at a higher risk for metabolic syndrome in adulthood. Although well-documented, the body fat distribution and mechanisms behind weight gain in narcolepsy are still not fully understood but may be related to the loss of orexin associated with the disease. Orexin has been linked to the regulation of brown adipose tissue (BAT), a metabolically active fat involved in energy homeostasis. Previous studies have used BMI and waist circumference to characterize adipose tissue increases in narcolepsy but none have investigated its specific distribution. Here, we examine adipose tissue distribution in 19 adolescent patients with narcolepsy type 1 and compare them to 17 of their healthy peers using full body magnetic resonance imaging (MRI). In line with previous findings we saw that the narcolepsy patients had more overall fat than the healthy controls, but contrary to our expectations there were no group differences in supraclavicular BAT, suggesting that orexin may have no effect at all on BAT, at least under thermoneutral conditions. Also, in line with previous reports, we observed that patients had more total abdominal adipose tissue (TAAT), however, we found that they had a lower ratio between visceral adipose tissue (VAT) and TAAT indicating a relative increase of subcutaneous abdominal adipose tissue (ASAT). This relationship between VAT and ASAT has been associated with a lower risk for metabolic disease. We conclude that while weight gain in adolescents with narcolepsy matches that of central obesity, the lower VAT ratio may suggest a lower risk of developing metabolic disease. ; Funding Agencies|Research Council of South East Sweden [FORSS-480551]; Knut and Alice Wallenberg foundation [KAW 2013.0076] |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | Frontiers in Endocrinology, 2018, 9; orcid:0000-0002-9267-2191; orcid:0000-0002-6189-0807; orcid:0000-0002-2167-2450; http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-153502Test; ISI:000452268600001 |
| DOI: | 10.3389/fendo.2018.00728 |
| الإتاحة: | https://doi.org/10.3389/fendo.2018.00728Test http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-153502Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.BC8B47C4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fendo.2018.00728 |
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