دورية أكاديمية
Eremoxylarins D–J, Antibacterial Eremophilane Sesquiterpenes Discovered from an Endolichenic Strain of Xylaria hypoxylon
| العنوان: | Eremoxylarins D–J, Antibacterial Eremophilane Sesquiterpenes Discovered from an Endolichenic Strain of Xylaria hypoxylon |
|---|---|
| المؤلفون: | Miral, Alice, Ferron, Solenn, Rouaud, Isabelle, Slyambayev, Dinmukhammed, Bousarghin, Latifa, Camuzet, Charline, Belouzard, Sandrine, Séron, Karin, Le Pogam, Pierre, Tranchimand, Sylvain, Tomasi, Sophie |
| المساهمون: | Institut des Sciences Chimiques de Rennes ISCR, Nutrition, Métabolismes et Cancer NuMeCan, Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 CIIL, Biomolécules : Conception, Isolement, Synthèse BioCIS |
| بيانات النشر: | American Chemical Society |
| سنة النشر: | 2023 |
| المجموعة: | LillOA (Lille Open Archive - Université de Lille) |
| مصطلحات موضوعية: | Bioactive compounds, Fungal compounds, Structural identification, Specialized metabolites |
| الوصف: | An endolichenic strain of the Ascomycetaceous Xylaria hypoxylon, cultivated alone or in coculture with another endolichenic fungus Dendrothyrium variisporum, produced seven new bioactive eremophilane sesquiterpenes eremoxylarins D−J (1−7). The isolated compounds disclosed a high similarity with the eremophilane core of the bioactive integric acid, and structures were elucidated by 1D and 2D NMR spectra and electronic circular dichroism (ECD) analyses. Eremoxylarins D, F, G, and I showed a selective activity against Gram-positive bacteria such as methicillin-resistant Staphylococcus aureus with minimum inhibitory concentration (MIC) values between 0.39 and 12.5 μg/mL. Eremoxylarin I, the most antibacterial active sesquiterpene, was also active against HCoV-229E at a concentration nontoxic to the hepatoma Huh-7 cell line with an 50% inhibitory concentration (IC 50) of 18.1 μM and a 50% cytotoxic concentration (CC 50) of 46.6 μM. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | Journal of Natural Products; http://hdl.handle.net/20.500.12210/80103Test |
| الإتاحة: | https://doi.org/20.500.12210/80103Test https://hdl.handle.net/20.500.12210/80103Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.1F5F238C |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |