دورية أكاديمية
Report of consensus Panel 4 from the 11th International Workshop on Waldenstrom's macroglobulinemia on diagnostic and response criteria.
| العنوان: | Report of consensus Panel 4 from the 11th International Workshop on Waldenstrom's macroglobulinemia on diagnostic and response criteria. |
|---|---|
| المؤلفون: | Treon, Steven P., Tedeschi, Alessandra, San-Miguel, Jesus, Garcia-Sanz, Ramon, Anderson, Kenneth C., Kimby, Eva, Minnema, Monique C., Benevolo, Giulia, Qiu, Lugui, Yi, Shuhui, Terpos, Evangelos, Tam, Constantine S., Castillo, Jorge J., Morel, Pierre, Dimopoulos, Meletios A., Owen, Roger G. |
| المساهمون: | Université de Lille, CHU Lille, Dana-Farber Cancer Institute Boston, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Clínica Universidad de Navarra Pamplona, Universidad de Salamanca, Karolinska Institutet Stockholm, University Medical Center Utrecht, Turin Polytechnic University Tashkent, China Academy of Chinese Medical Sciences, University of Athens Medical School Athens, University of Melbourne, CHU Amiens-Picardie, METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694, Leeds Teaching Hospitals NHS Trust |
| سنة النشر: | 2024 |
| المجموعة: | LillOA (Lille Open Archive - Université de Lille) |
| مصطلحات موضوعية: | MYD88, IgM, Response assessment, Diagnostic criteria, IgM MGUS, Waldenstrom's Macroglobulinemia |
| الوصف: | Consensus Panel 4 (CP4) of the 11th International Workshop on Waldenstrom's Macroglobulinemia (IWWM-11) was tasked with reviewing the current criteria for diagnosis and response assessment. Since the initial consensus reports of the 2nd International Workshop, there have been updates in the understanding of the mutational landscape of IgM related diseases, including the discovery and prevalence of MYD88 and CXCR4 mutations; an improved recognition of disease related morbidities attributed to monoclonal IgM and tumor infiltration; and a better understanding of response assessment based on multiple, prospective trials that have evaluated diverse agents in Waldenstrom's macroglobulinemia. The key recommendations from IWWM-11 CP4 included: (1) reaffirmation of IWWM-2 consensus panel recommendations that arbitrary values for laboratory parameters such as minimal IgM level or bone marrow infiltration should not be used to distinguish Waldenstrom's macroglobulinemia from IgM MGUS; (2) delineation of IgM MGUS into 2 subclasses including a subtype characterized by clonal plasma cells and MYD88 wild-type, and the other by presence of monotypic or monoclonal B cells which may carry the MYD88 mutation; and (3) recognition of “simplified” response assessments that use serum IgM only for determining partial and very good partial responses (simplified IWWM-6/new IWWM-11 response criteria). Guidance on response determination for suspected IgM flare and IgM rebound related to treatment, as well as extramedullary disease assessment was also updated and included in this report. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/octet-stream |
| اللغة: | English |
| العلاقة: | Seminars in Hematology; Semin Hematol; http://hdl.handle.net/20.500.12210/89796Test |
| الإتاحة: | https://doi.org/20.500.12210/89796Test https://hdl.handle.net/20.500.12210/89796Test |
| رقم الانضمام: | edsbas.C7725F72 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |