التفاصيل البيبلوغرافية
| العنوان: |
The hepatocyte insulin receptor is required to program the liver clock and rhythmic gene expression |
| المؤلفون: |
Fougeray, Tiffany, Polizzi, Arnaud, Régnier, Marion, Fougerat, Anne, Ellero-Simatos, Sandrine, Lippi, Yannick, Smati, Sarra, Lasserre, Frédéric, Tramunt, Blandine, Huillet, Marine, Dopavogui, Léonie, Salvi, Juliette, Nédélec, Emmanuelle, Gigot, Vincent, Smith, Lorraine, Naylies, Claire, Sommer, Caroline, Haas, Joel T., Wahli, Walter, Duez, Hélène, Gourdy, Pierre, Gamet-Payrastre, Laurence, Benani, Alexandre, Burnol, Anne-Françoise, Loiseau, Nicolas, Postic, Catherine, Montagner, Alexandra, Guillou, Hervé |
| المساهمون: |
ToxAlim ToxAlim, Institut des Maladies Métaboliques et Casdiovasculaires UPS/Inserm U1297 - I2MC, Toxicologie Intégrative & Métabolisme ToxAlim-TIM, Transcriptomic impact of Xenobiotics E23 TRiX, ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 ITX-lab, Service Diabétologie CHU Toulouse, Centre des Sciences du Goût et de l'Alimentation Dijon CSGA, Université Bourgogne Franche-Comté COMUE UBFC, Plateforme Ezop Ezop, Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 EGID, Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 RNMCD, Unité de biologie Moléculaire, Cellulaire et du Développement MCD, Center for Integrative Genomics - Institute of Bioinformatics, Génopode CIG, Lee Kong Chian School of Medicine, Institut Cochin IC UM3 (UMR 8104 / U1016) |
| بيانات النشر: |
Elsevier Inc |
| سنة النشر: |
2022 |
| المجموعة: |
LillOA (Lille Open Archive - Université de Lille) |
| مصطلحات موضوعية: |
CLOCK, CP: Metabolism, CP: Molecular biology, circadian, hepatocyte, insulin, insulin receptor, liver, metabolism |
| الوصف: |
Liver physiology is circadian and sensitive to feeding and insulin. Food intake regulates insulin secretion and is a dominant signal for the liver clock. However, how much insulin contributes to the effect of feeding on the liver clock and rhythmic gene expression remains to be investigated. Insulin action partly depends on changes in insulin receptor (IR)-dependent gene expression. Here, we use hepatocyte-restricted gene deletion of IR to evaluate its role in the regulation and oscillation of gene expression as well as in the programming of the circadian clock in the adult mouse liver. We find that, in the absence of IR, the rhythmicity of core-clock gene expression is altered in response to day-restricted feeding. This change in core-clock gene expression is associated with defective reprogramming of liver gene expression. Our data show that an intact hepatocyte insulin receptor is required to program the liver clock and associated rhythmic gene expression. ; 39 ; 2 |
| نوع الوثيقة: |
other/unknown material |
| وصف الملف: |
application/octet-stream |
| اللغة: |
English |
| تدمد: |
35417722 |
| العلاقة: |
ISITE " BFC; Cell Reports; http://hdl.handle.net/20.500.12210/108746Test |
| الإتاحة: |
https://doi.org/20.500.12210/108746Test
https://hdl.handle.net/20.500.12210/108746Test |
| حقوق: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.E9A0743C |
| قاعدة البيانات: |
BASE |
