دورية أكاديمية
Toxoplasmosis in patients with an autoimmune disease and immunosuppressive agents: A multicenter study and literature review
| العنوان: | Toxoplasmosis in patients with an autoimmune disease and immunosuppressive agents: A multicenter study and literature review |
|---|---|
| المؤلفون: | Durieux, Marie-Fleur, Lopez, Jean-Guillaume, Banjari, Maher, Passebosc-Faure, Karine, Brenier-Pinchart, Marie-Pierre, Christophe, Parisse, Gargala, Gilles, Berthier, Sabine, Bonhomme, Julie, Chemla, Cathy, Villena, Isabelle, Florian, Pierre, Frealle, Émilie, L'Ollivier, Coralie, Lussac-Sorton, Florian, Montoya, Vanessa, Cateau, Estelle, Pomares, Christelle, Simon, Loïc, Quinio, Dorothée, Robert-Gangneux, Florence, Medina, Yeray Novoa, Labriffe, Marc, Fauchais, Anne-Laure, Dardé, Marie-Laure |
| المساهمون: | Université de Lille, CHU Lille, Institut Pasteur de Lille, Service de Parasitologie Mycologie CHU Limoges, Service de Parasitologie-Mycologie CHRU LIlle |
| بيانات النشر: | Public Library of Science |
| سنة النشر: | 2024 |
| المجموعة: | LillOA (Lille Open Archive - Université de Lille) |
| الوصف: | Background Cases of Toxoplasma reactivation or more severe primary infection have been reported in patients receiving immunosuppressive (IS) treatment for autoimmune diseases (AID). The purpose of this study was to describe features of toxoplasmosis occurring in patients with AID treated by IS therapy, excluded HIV-positive and transplant patients. Methods A multicenter descriptive study was conducted using data from the French National Reference Center for Toxoplasmosis (NRCT) that received DNA extracts or strains isolated from patients, associated with clinical data. Other cases were retrieved through a questionnaire sent to all French parasitology and internal medicine departments. Furthermore, a systematic literature review was conducted. Results 61 cases were collected: 25 retrieved by the NRCT and by a call for observations and 36 from a literature review. Half of the cases were attributed to reactivation (50.9%), and most of cases (49.2%) were cerebral toxoplasmosis. The most common associated AID were rheumatoid arthritis (28%) and most frequent treatments were antimetabolites (44.3%). Corticosteroids were involved in 60.7% of cases. Patients had a favorable outcome (50.8%) but nine did not survive. For 12 cases, a successful Toxoplasma strain characterization suggested the possible role of this parasitic factor in ocular cases. Conclusion Although this remains a rare condition, clinicians should be aware for the management of patients and for the choice of IS treatment. ; 16 |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/octet-stream |
| اللغة: | English |
| العلاقة: | PLoS Neglected Tropical Diseases; PLoS Negl Trop Dis; http://hdl.handle.net/20.500.12210/88423Test |
| الإتاحة: | https://doi.org/20.500.12210/88423Test https://hdl.handle.net/20.500.12210/88423Test |
| حقوق: | Attribution 3.0 United States ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.EE16AB0A |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |