دورية أكاديمية
Interleukin-7, a new cytokine targeting the mouse hypothalamic arcuate nucleus: role in body weight and food intake regulation
| العنوان: | Interleukin-7, a new cytokine targeting the mouse hypothalamic arcuate nucleus: role in body weight and food intake regulation |
|---|---|
| المؤلفون: | Macia, Laurence, Viltart, Odile, Delacre, Myriam, Sachot, Christelle, Héliot, Laurent, Di Santo, James P, Wolowczuk, Isabelle |
| المساهمون: | Université de Lille, CNRS, CHU Lille, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U1172 Inserm - U837 JPArc, Institut Pasteur de Lille, Institut Pasteur Paris IP |
| سنة النشر: | 2024 |
| المجموعة: | LillOA (Lille Open Archive - Université de Lille) |
| مصطلحات موضوعية: | Animals, Appetite Regulation, Body Weight, Brain Chemistry, Hypothalamus, Interleukin-7, Mice, Neurons, Obesity, Phosphorylation, Receptors, STAT3 Transcription Factor |
| الوصف: | Body weight is controlled through peripheral (white adipose tissue) and central (mainly hypothalamus) mechanisms. We have recently obtained evidence that overexpression of interleukin (IL)-7, a critical cytokine involved in lymphopoiesis, can protect against the development of diet-induced obesity in mice. Here we assessed whether IL-7 mediated its effects by modulating hypothalamic function. Acute subcutaneous injection of IL-7 prevented monosodium glutamate-induced obesity, this being correlated with partial protection against cell death in the hypothalamic arcuate nucleus (ARC). Moreover, we showed that IL-7 activated hypothalamic areas involved in regulation of feeding behavior, as indicated by induction of the activation marker c-Fos in neural cells located in the ventromedial part of the ARC and by inhibition of food intake after fasting. Both chains of the IL-7 receptor (IL-7Ralpha and gamma(c)) were expressed in the ARC and IL-7 injection induced STAT-3 phosphorylation in this area. Finally, we established that IL-7 modulated the expression of neuropeptides that tune food intake, with a stimulatory effect on the expression of pro-opiomelanocortin and an inhibitory effect on agouti-related peptide expression in accordance with IL-7 promoting anorectic effects. These results suggest that the immunomodulatory cytokine IL-7 plays an important and unappreciated role in hypothalamic body weight regulation. ; 5 |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/octet-stream; application/rdf+xml; charset=utf-8 |
| اللغة: | English |
| العلاقة: | PLoS ONE; http://hdl.handle.net/20.500.12210/101372Test |
| الإتاحة: | https://doi.org/20.500.12210/101372Test https://hdl.handle.net/20.500.12210/101372Test |
| حقوق: | Attribution 3.0 United States ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.BFE104B0 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |