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Increased risk of severe COVID-19 in hospitalized patients with SARS-CoV-2 Alpha variant infection: a multicentre matched cohort study

التفاصيل البيبلوغرافية
العنوان: Increased risk of severe COVID-19 in hospitalized patients with SARS-CoV-2 Alpha variant infection: a multicentre matched cohort study
المؤلفون: Martin-Blondel, Guillaume, Lescure, François-Xavier, Assoumou, Lambert, Charpentier, Charlotte, Chapplain, Jean-Marc, Perpoint, Thomas, Grouteau, Gaspard, Cordel, Hugues, Pialoux, Gilles, Pacanowski, Jérome, Thy, Michael, Bauvois, Adeline, Laureillard, Didier, Hamrouni, Fadia, Algarte-Genin, Michèle, Poissy, Julien, Descamps, Diane, Costagliola, Dominique, Delobel, Pierre, Henaff, Jean Roch Le, Mear, Vincent, Lagarrigues, Sandra, Frelat, Alais, Nadai, Thomas De, Steinmeyer, Zara, Bello, Arnaud Del, Ruiz, Stéphanie, Sarton, Benjamine, Noel-Savina, Elise, Izopet, Jacques, Peiffer-Smadja, Nathan, Gare, Mathilde, Pluart, Diane Le, Rioux, Christophe, Deconinck, Laurène, Yazdanpanah, Yazdan, Tattevin, Pierre, Bouscambert-Duchamp, Maude, Yonis, Hodane, Chabert, Paul, Mohamed-Kassim, Youssouf, Hassold, Nolan, Brichler, Segolène, Caliez, Julien, Rambaud, Thomas, Lopez-Sublet, Marilucy, Adnet, Frédéric, Palacios, Christia, Bachir, Marwa, Nadal, Marine, Turpin, Mathieu, Parrot, Antoine, Fofana, Djeneba, Lacombe, Karine, Gras, Emmanuelle, Levi, Laura, Surgers, Laure, Devred, Ines, Valin, Nadia, Chiarabini, Thibault, Meynard, Jean Luc, Duran, Clara, Gault, Elyanne, Kahn, Jean-Emmanuel, Rouveix, Elisabeth, Geri, Guillaume, Sotto, Albert, Loubet, Paul, Roger, Claire, Lambert, Marc, Assaf, Ady, Bocket, Laurence, Bani-Sadr, Firouzé, N’guyen, Yohan, Romaru, Juliette, Hentzien, Maxime, Gabas, Thomas, Chabrol, Amélie, Billiou, Cecilia, Menager, Philippe, Billy, Christophe, Laurichesse, Jean-Jacques, Simba, Fabrice Ketty N., Paz, Pauline Caraux, Tinang, Liliane, Bounhiol, Agathe, Burnat, Catherine, Soriot-Thomas, Sandrine, Basille, Damien, Lanoix, Jean Philippe, Zerbib, Yoan, Zerbib, Yoann, Pouvaret, Anne, Lanternier, Fanny, Mascitti, Helene, Dinh, Aurélien, Davido, Benjamin, Lesprit, Philippe, Farfour, Eric, Neuville, Mathilde, Allaoua, Linda Nait, Lejaille, Michèle, Castro, Nathalie De, Molina, Jean-Michel, Ponscarme, Diane, Tateo, Mariagrazia, Liegeon, Geoffroy, Boussen, Ines, Huriez, Pauline, Cabié, André, Campana, Valentine, Calmont, Isabelle, Turmel, Jean-Marie, Karine, Guitteaud, Sandrine, Pierre-François, Marquise, Athéna, Cabras, Ornella, Lehoux, Mélanie, Chabartier, Cyrille, Dubee, Vincent, Ndiaye, Diama, Lefeuvre, Caroline, Kouatchet, Achille, Nguyen, Duc, Tumiotto, Camille, Sioniac, Pierre, Boyer, Alexandre, Faucher, Jean-François, Desvaux, Edouard, Rogez, Sylvie, Turnier, Paul Le, Raffi, François, Canet, Emmanuel, Roquilly, Antoine, Castain, Louise, Secher, Solène, Mondain, Véronique, Piroth, Lionel, Auvray, Christelle, Chavanet, Pascal, Buisson, Marielle, Mahy, Sophie, Catherine, François-Xavier, Esteve, Clementine, Duong, Michel, Charles, Carole, Gohier, Sandrine, Schaffer, Céline, Robineau, Olivier, Bortolotti, Perrine, Pradier, Maxime, Goehringer, Francois, Corbel, Alice, Kotzyba, Jeanne, Alexandre, Kévin, Beduneau, Gaetan, Alessandri-Gradt, Elodie, Martinot, Martin, Gravier, Simon, Ion, Ciprian, Lastours, Victoire De, Rahli, Roza, Garrait, Valérie, Richier, Laurent, Smati-Lafarge, Mounira, Frémont, Guillemette, Nivose, Pierre Louis, André, Marie Hélène, Gerin, Magdalena, Hamdi, Aicha, Sayre, Naomi, Cossec, Stephanie, Alviset, Sophie, Billy, Pierre Alain, Gousseff, Marie, Forestier, Emmanuel, Destrem, Anne-Laure, Rogeaux, Olivier, Bosch, Alexie, Bryant, Sabrina, Bourgeois, Gaëlle, Schaller, Ophélie dos Santos, Carret, Marie-Christine, Ettahar, Nicolas, Moudjahed, Haciba, Leone, Nathalie, Djennaoui, Mehdi, Lefebvre, Nicolas, Ursenbach, Axel, Danion, François, Ruch, Yvon, Solis, Morgane, Merdji, Hamid, Kassègne, Loïc, Pommeret, Fanny, Blameble, Emeline Colomba, Manssouria, Merad, Stoclin, Annabelle, Griscelli, Franck, Deriaz, Sophie, Oziol, Eric, Favier, Laurent, Obiols, Julien, Gicquel, Pascal, Rapp, Christophe, Louvet, Laurence, Ihout, Paul, Zabbé, Jean-Benoit, Bellec, Laurent, Chroboczek, Tomasz, Mégessier, Sandrine, Lacoste, Marie, Viala, Benjamin, Challan-Belval, Thibaut, Wackenheim, Chloé, Letertre-Gibert, Paule, Grossi, Olivier
المساهمون: Service Maladies infectieuses et tropicales CHU Toulouse, Institut Toulousain des Maladies Infectieuses et Inflammatoires Infinity, Services de Maladies Infectieuses et Tropicales CHU Bichat, Stratégies thérapeutiques contre l'infection VIH et les maladies virales associées iPLesp THERAVIR, Infection, Anti-microbiens, Modélisation, Evolution IAME (UMR_S_1137 / U1137), Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Ponchaillou, Service des Maladies Infectieuses et Tropicales Lyon, Service de maladies infectieuses et tropicales CHU Avicenne, CHU Tenon AP-HP, CHU Saint-Antoine AP-HP, Service de médecine interne CHU Ambroise Paré, Centre Hospitalier Universitaire de Nîmes CHU Nîmes, Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 UGSF, Service Obstétrique CHU Toulouse, Gérontopôle, Institut du Vieillissement, Centre Hospitalier Universitaire de Toulouse CHU Toulouse, Pôle Anesthésie Réanimation CHU de Toulouse, Toulouse NeuroImaging Center ToNIC, Pôle Clinique des Voies respiratoires CHU Toulouse, Laboratoire Virologie CHU Toulouse, Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique MERIT - UMR_D 261, Hôpital Foch Suresnes, AP-HP - Hôpital Bichat - Claude Bernard Paris, Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 RID-AGE
بيانات النشر: BioMed Central
سنة النشر: 2022
المجموعة: LillOA (Lille Open Archive - Université de Lille)
مصطلحات موضوعية: COVID-19, SARS-CoV-2, Variant of concern Alpha, Severity, Aged, Cohort Studies, Female, Hospitalization, Humans, Male, Retrospective Studies
الوصف: Background: The impact of the variant of concern (VOC) Alpha on the severity of COVID-19 has been debated. We report our analysis in France.Methods: We conducted an exposed/unexposed cohort study with retrospective data collection, comparing patients infected by VOC Alpha to contemporaneous patients infected by historical lineages. Participants were matched on age (± 2.5 years), sex and region of hospitalization. The primary endpoint was the proportion of hospitalized participants with severe COVID-19, defined as a WHO-scale > 5 or by the need of a non-rebreather mask, occurring up to day 29 after admission. We used a logistic regression model stratified on each matched pair and accounting for factors known to be associated with the severity of the disease.Results: We included 650 pairs of patients hospitalized between Jan 1, 2021, and Feb 28, 2021, in 47 hospitals. Median age was 70 years and 61.3% of participants were male. The proportion of participants with comorbidities was high in both groups (85.0% vs 90%, p = 0.004). Infection by VOC Alpha was associated with a higher odds of severe COVID-19 (41.7% vs 38.5%-aOR = 1.33 95% CI [1.03-1.72]).Conclusion: Infection by the VOC Alpha was associated with a higher odds of severe COVID-19. ; 22
نوع الوثيقة: other/unknown material
وصف الملف: application/octet-stream
اللغة: English
العلاقة: BMC infectious diseases; http://hdl.handle.net/20.500.12210/109913Test
الإتاحة: https://doi.org/20.500.12210/109913Test
https://hdl.handle.net/20.500.12210/109913Test
حقوق: info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.569F3E99
قاعدة البيانات: BASE
الوصف
الوصف غير متاح.