دورية أكاديمية
Invasive pulmonary aspergillosis among intubated patients with SARS-CoV-2 or influenza pneumonia: a European multicenter comparative cohort study
| العنوان: | Invasive pulmonary aspergillosis among intubated patients with SARS-CoV-2 or influenza pneumonia: a European multicenter comparative cohort study |
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| المؤلفون: | Rouzé, Anahita, Lemaitre, Elise, Martin-Loeches, Ignacio, Povoa, Pedro, Diaz, Emili, Nyga, Rémy, Torres, Antoni, Metzelard, Matthieu, Du Cheyron, Damien, Lambiotte, Fabien, Tamion, Fabienne, Labruyere, Marie, Boulle Geronimi, Claire, Luyt, Charles-Edouard, Nyunga, Martine, Pouly, Olivier, Thille, Arnaud, Megarbane, Bruno, Saade, Anastasia, Magira, Eleni, Llitjos, Jean-François, Ioannidou, Iliana, Pierre, Alexandre, Reignier, Jean, Garot, Denis, Kreitmann, Louis, Baudel, Jean-Luc, Voiriot, Guillaume, Plantefeve, Gaëtan, Morawiec, Elise, Asfar, Pierre, Boyer, Alexandre, Mekontso-Dessap, Armand, Makris, Demosthenes, Vinsonneau, Christophe, Floch, Pierre-Edouard, Marois, Clémence, Ceccato, Adrian, Artigas, Antonio, Gaudet, Alexandre, Nora, David, Cornu, Marjorie, Duhamel, Alain, Labreuche, Julien, Nseir, Saad |
| المساهمون: | Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 UGSF, CHU Amiens-Picardie, Centre hospitalier Valenciennes, Nord, Endothélium, valvulopathies et insuffisance cardiaque EnVI, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand CHU Dijon, Centre Hospitalier Douai, Nord, CIC - Poitiers, Optimisation thérapeutique en Neuropsychopharmacologie OPTeN (UMR_S_1144 / U1144), Service de Réanimation Médicale et Toxicologique Hôpital Lariboisière, Hopital Saint-Louis AP-HP AP-HP, Hôpital Cochin AP-HP, Centre Hospitalier de Lens, Centre hospitalier universitaire de Nantes CHU Nantes, Hôpital Bretonneau, CHU Saint-Antoine AP-HP, CHU Tenon AP-HP, Centre Hospitalier Victor Dupouy, CHU Pitié-Salpêtrière AP-HP, Neurophysiologie Respiratoire Expérimentale et Clinique UMRS 1158, Centre Hospitalier Universitaire d'Angers CHU Angers, CHU Bordeaux Bordeaux, Groupe de recherche clinique CARMAS (Cardiovascular and Respiratory Manifestations of Acute lung injury and Sepsis) CARMAS, Institut Mondor de Recherche Biomédicale IMRB, Centre de Recherche Saint-Antoine CRSA, Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 CIIL |
| بيانات النشر: | BioMed Central |
| سنة النشر: | 2022 |
| المجموعة: | LillOA (Lille Open Archive - Université de Lille) |
| مصطلحات موضوعية: | COVID-19, Intensive care unit, Invasive pulmonary aspergillosis, Mechanical ventilation, Severe influenza |
| الوصف: | Background Recent multicenter studies identified COVID-19 as a risk factor for invasive pulmonary aspergillosis (IPA). However, no large multicenter study has compared the incidence of IPA between COVID-19 and influenza patients. Objectives To determine the incidence of putative IPA in critically ill SARS-CoV-2 patients, compared with influenza patients. Methods This study was a planned ancillary analysis of the coVAPid multicenter retrospective European cohort. Consecutive adult patients requiring invasive mechanical ventilation for > 48 h for SARS-CoV-2 pneumonia or influenza pneumonia were included. The 28-day cumulative incidence of putative IPA, based on Blot definition, was the primary outcome. IPA incidence was estimated using the Kalbfleisch and Prentice method, considering extubation (dead or alive) within 28 days as competing event. Results A total of 1047 patients were included (566 in the SARS-CoV-2 group and 481 in the influenza group). The incidence of putative IPA was lower in SARS-CoV-2 pneumonia group (14, 2.5%) than in influenza pneumonia group (29, 6%), adjusted cause-specific hazard ratio (cHR) 3.29 (95% CI 1.53–7.02, p = 0.0006). When putative IPA and Aspergillus respiratory tract colonization were combined, the incidence was also significantly lower in the SARS-CoV-2 group, as compared to influenza group (4.1% vs. 10.2%), adjusted cHR 3.21 (95% CI 1.88–5.46, p < 0.0001). In the whole study population, putative IPA was associated with significant increase in 28-day mortality rate, and length of ICU stay, compared with colonized patients, or those with no IPA or Aspergillus colonization. Conclusions Overall, the incidence of putative IPA was low. Its incidence was significantly lower in patients with SARS-CoV-2 pneumonia than in those with influenza pneumonia. Clinical trial registration The study was registered at ClinicalTrials.gov, number NCT04359693 . ; 26 ; 1 |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/octet-stream |
| اللغة: | English |
| العلاقة: | Critical Care; http://hdl.handle.net/20.500.12210/78541Test |
| الإتاحة: | https://doi.org/20.500.12210/78541Test https://hdl.handle.net/20.500.12210/78541Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.D5D09046 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |