دورية أكاديمية
Sodium-glucose cotransporter 2 inhibitors and mitochondrial functions: state of the art.
| العنوان: | Sodium-glucose cotransporter 2 inhibitors and mitochondrial functions: state of the art. |
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| المؤلفون: | Yaribeygi, Habib, Maleki, Mina, Sahebkar, Amirhossein, Butler, Alexandra, Jami, Tannaz |
| المصدر: | EXCLI journal ; 22 ; 53 ; 66 ; Germany |
| سنة النشر: | 2023 |
| المجموعة: | Lenus - Irish Health Publications Archive (HSE - Health Service Executive) |
| مصطلحات موضوعية: | mitophagy, oxidative stress, sodium-glucose cotransporter 2 inhibitors, DIABETES MELLITUS, mitochondria |
| الوصف: | Sodium-glucose cotransporter 2 inhibitors (SGLT2is) are a class of newly introduced antidiabetic drugs with potent hypoglycemic effects. Recent evidence suggests that these drugs have extraglycemic impacts and are therefore able to provide additional benefits beyond glucose lowering. Mitochondrial dysfunction is a central facet of many disorders that negatively impacts many tissues and organs, especially in the setting of diabetes. Therefore, it would be hugely beneficial if an antidiabetic drug could also provide mitochondrial benefits to improve cellular function and reduce the risk of diabetic complications. In this review, we have surveyed the literature for possible mitochondrial benefits of SGLT2is and we discuss the possible mechanisms involved. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1611-2156 |
| العلاقة: | http://hdl.handle.net/10147/635474Test; EXCLI journal; PMC9939776 |
| DOI: | 10.17179/excli2022-5482 |
| الإتاحة: | https://doi.org/10.17179/excli2022-5482Test http://hdl.handle.net/10147/635474Test |
| حقوق: | Copyright © 2023 Yaribeygi et al. |
| رقم الانضمام: | edsbas.7DEDFBFD |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16112156 |
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| DOI: | 10.17179/excli2022-5482 |