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1دورية أكاديمية
المؤلفون: Bazarova, Alina, Bhandari, Pradeep, Cannatelli, Rosanna, Daperno, Marco, Ferraz, Jose, Goetz, Martin, Gui, Xianyong, Hayee, Bu, De Hertogh, Gert, Lazarev, Mark, Li, Ji, Parra-Blanco, Adolfo, Pastorelli, Luca, Panaccione, Remo, Occhipinti, Vincenzo, Rath, Timo, Smith, Samuel C L, Shivaji, Uday N, Tontini, Gian Eugenio, Vieth, Michael, Villanacci, Vincenzo, Zardo, Davide, Kiesslich, Ralf, Ghosh, Subrata, Nardone, Olga Maria, Bisschops, Raf, IACUCCI, MARIETTA
المصدر: United European gastroenterology journal ; 10 ; 2 ; 147 ; 159 ; United Kingdom ; England
مصطلحات موضوعية: ulcerative colitis, virtual electronic chromoendoscopy - PICaSSO - clinical outcomes - prediction, endoscopic remission, histological remission, mucosal healing
الوصف: Background and aims: A composite endoscopic-histologic remission is increasingly explored as an important endpoint in ulcerative colitis (UC). We investigated combined endoscopic-histologic remission for predicting clinical outcomes at 12 months compared with endoscopic remission alone using the high definition virtual chromoendoscopy (VCE) Paddington International virtual ChromoendoScopy ScOre (PICaSSO) and histology scores. Methods: Ulcerative colitis patients, prospectively enrolled from 11 international centres, underwent VCE with targeted biopsies and followed up for 12 months. Endoscopic activity was assessed by Mayo Endoscopic Score (MES), Ulcerative Colitis Endoscopic Index Severity (UCEIS) followed by VCE-PICaSSO. Robarts Histopathological Index|Robarts Histological index≤3 without neutrophils in mucosa, and Nancy Histological index (NHI)≤ 1 were used to define histologic remission. Combined endoscopic-histologic remission was compared with endoscopic remission alone by Cox proportional hazards model and by two- and three-proportion analysis using pre-specified clinical outcomes. Results: 307 patients were recruited and 302 analysed. There was no difference in survival without specified clinical outcomes between PICaSSO defined endoscopic remission alone and endoscopic plus histologic remission in the rectum (HR 0.42, 95%CI 0.16-1.11 and HR 1.03, 95%CI 0.42-2.52 for Robarts Histological index and NHI respectively) at 12 months. There was however a significant survival advantage without specified clinical outcome events for UCEIS combined with histology compared with UCEIS alone (HR 0.30, 95%CI 0.12-0.75, p = 0.02) at 12 months (but not combined with NHI). For MES there was no advantage for predicting specified clinical outcomes at 12 months for endoscopy alone versus endoscopy plus histology, but there were differences in two and three proportion analysis at 6 months. Conclusion: Endoscopic remission by VCE-PICaSSO alone was similar to combined endoscopic and histologic remission for predicting ...
العلاقة: http://hdl.handle.net/10147/635552Test; United European gastroenterology journal; PMC8911539
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المؤلفون: Fismen, Anne-Siri, Smith, Otto Robert Frans, Helleve, Arnfinn, Haug, Ellen, Chatelan, Angeline, Kelly, Colette, Dzielska, Anna, Nardone, Paola, Melkumova, Marina, Ercan, Oya, Kopcakova, Jaroslava, Lazzeri, Giacomo, Klepp, Knut-Inge, Samdal, Oddrun
المصدر: SSM - population health ; 19 ; 101127 ; England
مصطلحات موضوعية: OVERWEIGHT, OBESITY, ADOLESCENTS
الوصف: Background: Trends of increased complexity in family structure have developed alongside increasing prevalence of overweight and obesity. This study examines cross-national variations in the likelihood of living with overweight and obesity among adolescents living with one parent versus two parents, as well as the influence of living with stepparents, grandparents and siblings. Furthermore, the study explores how these associations relate to age, gender and individual-level socioeconomic status (SES) and country-level SES. We hypothesised that adolescents living in one-parent versus two-parents families, were more likely to live with overweight and obesity. Methods: The study is based on nationally representative data from 41 countries participating in the 2013/14 Health Behaviors in School-Aged Children study (n = 211.798). Multilevel logistic regression analysis was used to examine the associations between family structure and overweight and obesity by age, gender, SES, and geographic region, among adolescents aged 11, 13 and 15 years. Results: Living with one versus two parent(s) was associated with a higher likelihood of overweight and obesity (ORadj.1.13, 95%CI 1.08,1.17). Age, gender, individual-level SES, and living with grandparents were also associated with a higher likelihood of overweight and obesity, whereas living with siblings was associated with a lower likelihood of overweight and obesity. The effect of family structure varied also by age and gender with no significant associations found between living with one parent and overweight and obesity in the 15-year-old age group. Some cross-national variation was observed, and this was partly explained by country-level SES. The effect of family structure increased by a factor 1.08 per one-unit change in country-level SES (OR 1.08, 95%CI1.03, 1.12). Conclusion: The study indicates that living in a one-parent family, as well as living together with grandparents, are associated with overweight and obesity among adolescents, particularly in the Nordic ...
العلاقة: http://hdl.handle.net/10147/635055Test; SSM - population health; PMC9168136
النص الكامل