دورية أكاديمية
PICaSSO virtual electronic chromendoscopy accurately reflects combined endoscopic and histological assessment for prediction of clinical outcomes in ulcerative colitis.
| العنوان: | PICaSSO virtual electronic chromendoscopy accurately reflects combined endoscopic and histological assessment for prediction of clinical outcomes in ulcerative colitis. |
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| المؤلفون: | Bazarova, Alina, Bhandari, Pradeep, Cannatelli, Rosanna, Daperno, Marco, Ferraz, Jose, Goetz, Martin, Gui, Xianyong, Hayee, Bu, De Hertogh, Gert, Lazarev, Mark, Li, Ji, Parra-Blanco, Adolfo, Pastorelli, Luca, Panaccione, Remo, Occhipinti, Vincenzo, Rath, Timo, Smith, Samuel C L, Shivaji, Uday N, Tontini, Gian Eugenio, Vieth, Michael, Villanacci, Vincenzo, Zardo, Davide, Kiesslich, Ralf, Ghosh, Subrata, Nardone, Olga Maria, Bisschops, Raf, IACUCCI, MARIETTA |
| المصدر: | United European gastroenterology journal ; 10 ; 2 ; 147 ; 159 ; United Kingdom ; England |
| سنة النشر: | 2022 |
| المجموعة: | Lenus - Irish Health Publications Archive (HSE - Health Service Executive) |
| مصطلحات موضوعية: | ulcerative colitis, virtual electronic chromoendoscopy - PICaSSO - clinical outcomes - prediction, endoscopic remission, histological remission, mucosal healing |
| الوصف: | Background and aims: A composite endoscopic-histologic remission is increasingly explored as an important endpoint in ulcerative colitis (UC). We investigated combined endoscopic-histologic remission for predicting clinical outcomes at 12 months compared with endoscopic remission alone using the high definition virtual chromoendoscopy (VCE) Paddington International virtual ChromoendoScopy ScOre (PICaSSO) and histology scores. Methods: Ulcerative colitis patients, prospectively enrolled from 11 international centres, underwent VCE with targeted biopsies and followed up for 12 months. Endoscopic activity was assessed by Mayo Endoscopic Score (MES), Ulcerative Colitis Endoscopic Index Severity (UCEIS) followed by VCE-PICaSSO. Robarts Histopathological Index|Robarts Histological index≤3 without neutrophils in mucosa, and Nancy Histological index (NHI)≤ 1 were used to define histologic remission. Combined endoscopic-histologic remission was compared with endoscopic remission alone by Cox proportional hazards model and by two- and three-proportion analysis using pre-specified clinical outcomes. Results: 307 patients were recruited and 302 analysed. There was no difference in survival without specified clinical outcomes between PICaSSO defined endoscopic remission alone and endoscopic plus histologic remission in the rectum (HR 0.42, 95%CI 0.16-1.11 and HR 1.03, 95%CI 0.42-2.52 for Robarts Histological index and NHI respectively) at 12 months. There was however a significant survival advantage without specified clinical outcome events for UCEIS combined with histology compared with UCEIS alone (HR 0.30, 95%CI 0.12-0.75, p = 0.02) at 12 months (but not combined with NHI). For MES there was no advantage for predicting specified clinical outcomes at 12 months for endoscopy alone versus endoscopy plus histology, but there were differences in two and three proportion analysis at 6 months. Conclusion: Endoscopic remission by VCE-PICaSSO alone was similar to combined endoscopic and histologic remission for predicting ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2050-6414 |
| العلاقة: | http://hdl.handle.net/10147/635552Test; United European gastroenterology journal; PMC8911539 |
| DOI: | 10.1002/ueg2.12185 |
| الإتاحة: | https://doi.org/10.1002/ueg2.12185Test http://hdl.handle.net/10147/635552Test |
| حقوق: | © 2021 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology. |
| رقم الانضمام: | edsbas.A77A567D |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20506414 |
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| DOI: | 10.1002/ueg2.12185 |