التفاصيل البيبلوغرافية
| العنوان: |
The natural history of aortic atherosclerosis: A systematic histopathological evaluation of the peri-renal region |
| المؤلفون: |
Dijk, R.A. van, Virmani, R., Thusen, J.H. von der, Schaapherder, A.F., Lindeman, J.H.N. |
| المصدر: |
Atherosclerosis |
| سنة النشر: |
2010 |
| المجموعة: |
Leiden Repository (Leiden University) |
| مصطلحات موضوعية: |
Atherosclerosis Aorta Macrophage infiltration Vulnerable plaque Inflammation sudden coronary death intraplaque hemorrhage plaque progression risk-factors vulnerable plaque lesions prevalence mechanisms disease classification |
| الوصف: |
Background: Risk factor profiles for the different vascular beds (i.e. coronary, carotid, peripheral and aortic) are remarkably different, suggesting that atherosclerosis is a heterogeneous disorder. Little is known about the morphologic progression of atherosclerosis in the peri-renal aorta, one of the primary predilection sites of atherosclerosis. Methods: A systematic analysis was performed in 260 consecutive peri-renal aortic patches (stained with Movat Pentachrome and H&E) collected during organ transplantation (mean donor age 46.5 (range 5-76) years; 54%.; mean BMI 24.9; 40% smokers; 20% hypertensive). Plaque morphology was classified according to the modified AHA classification scheme proposed by Virmani et al. [ 4]. Immunostaining against CD68 was used to identify the distribution of intimal macrophages and monocytes in several predefined locations among various plaque types and fibrous cap thickness. Results: There was significant intimal thickening (p < 0.013) and medial thinning (p < 0.032) with advancing age. The incidence of atherosclerotic plaques in the abdominal aorta correlated with age (r = 0.640, p = 0.01). During the first three decades of life adaptive intimal thickening and intimal xanthomas were the predominant lesions. In contrast, the fourth, fifth and sixth decades hallmarked more complicated plaques of pathological intimal thickening, early and late. broatheromas (EFAs and LFAs), thin-cap FAs (TCFAs; cap thickness < 155 mu m), ruptured plaques (PRs), healed rupture and fibrotic calcified plaques. The mean percentage of lesional macrophages increased significantly from LFAs to TCFAs (5-17%; p < 0.001). Macrophage infiltration of the fibrous cap was negatively correlated with fibrous cap thickness (p < 0.0004); TCFAs and PRs (caps < 100 mu m) contained significantly more macrophages (19%) compared with caps 101-300 mu m (6%) and > 300 mu m (2%). Macrophages in shoulder regions were highest in early and late FAs (similar to 45%) followed by TCFAs (27%) and PR ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
lumc-id: 4195888; https://hdl.handle.net/1887/106290Test |
| الإتاحة: |
https://hdl.handle.net/1887/106290Test |
| رقم الانضمام: |
edsbas.A8EB98B9 |
| قاعدة البيانات: |
BASE |
