دورية أكاديمية
Anthropometric, biochemical and hormonal profiles of the partially admixed pygmoid group in Rampasasa (Flores, Indonesia)
| العنوان: | Anthropometric, biochemical and hormonal profiles of the partially admixed pygmoid group in Rampasasa (Flores, Indonesia) |
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| المؤلفون: | Pulungan, A., Andarie, A.A., Soesanti, F., Yassien, M.R., Bruin, C. de, Wijaya, A., Firmansyah, A., Wit, J.M. |
| المصدر: | Journal of Pediatric Endocrinology and Metabolism |
| سنة النشر: | 2021 |
| المجموعة: | Leiden Repository (Leiden University) |
| مصطلحات موضوعية: | growth, head circumference, IGF-I, IGFBP-3, negritos, pygmies, short stature, vitamin D deficiency |
| الوصف: | Objectives: We performed a cross-sectional study on anthropometric and laboratory characteristics of inhabitants of Rampasasa (Flores, Indonesia). Adults were categorised according to ancestry into three groups: pygmoid (P/P, offspring of pygmoid parents, n=8), mixed pygmoid (P/N, offspring of pygmoid and non-pygmoid parents, n=12) and non-pygmoid (N/N, n=10). Children (n=28) were P/N.Methods: Measurements included height, weight, sitting height, arm span, head circumference, haematological analysis and serum albumin, calcium, vitamin D, insulin-like growth factor-I (IGF-I) and IGF binding protein 3 (IGFBP-3). Pubertal stage and bone age was assessed in children. Anthropometric data were expressed as standard deviation score (SDS) for age. IGF-I, IGFBP-3 and IGF-I/IGFBP-3 ratio were expressed as SDS for age, bone age and pubertal stage.Results: Mean height SDS showed a gradient from P/P (-4.0) via P/N (-3.2) to N/N (-2.3) (-3.4, -3.1 and -2.2 adjusted for age-associated shrinking). Sitting height and head circumference showed similar gradients. Serum IGF-I SDS was similar among groups (approximately -1 SDS). IGFBP-3 SDS tended toward a gradient from P/P (-1.9) via P/N (-1.5) to N/N (-1.1), but IGF-I/IGFBP-3 ratio was normal in all groups. In P/P and P/N, mean head circumference SDS was >2 SD greater than mean height SDS. Children showed a progressive growth failure and bone age delay, delayed female pubertal onset and an initial low serum IGF-I, normal IGFBP-3 and low IGF-I/IGFBP-3 ratio.Conclusions: P/P showed proportionate short stature with relative macrocephaly and relatively low IGFBP-3; P/N presented an intermediate pattern. P/N children were progressively short, showed delayed skeletal maturation, delayed puberty in girls and low IGF-I and IGF- I/IGFBP-3. ; Development |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | lumc-id: 176575049; https://hdl.handle.net/1887/3575997Test |
| DOI: | 10.1515/jpem-2020-0526/html |
| DOI: | 10.1515/jpem-2020-0526 |
| الإتاحة: | https://doi.org/10.1515/jpem-2020-0526Test https://hdl.handle.net/1887/3575997Test |
| رقم الانضمام: | edsbas.4EBB379D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1515/jpem-2020-0526/html |
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