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1مؤتمر
المصدر: Lietuvos endokrinologija : [mokslinė konferencija „Nutukimas: sprendimų beieškant“ : tezės : 2018 m. gegužės 25 d., Kaunas] / Lietuvos sveikatos mokslų universiteto Endokrinologijos klinika ir Endokrinologijos institutas. Lietuvos endokrinologų draugija. Kauno endokrinologijos mokslų klubas, Kaunas : Medicininės informacijos centras, 2018, t. 26, Nr. 1, p. 13-13 ; ISSN 1392-7213
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2مؤتمر
المصدر: 9th International Symposium on Diabetes, Hypertension, Metabolic Syndrome & Pregnancy (DIP 2017) "Maternal Medicine meets Fetal Medicine" : March 8-12, 2017, Barcelona, Spain, Barcelona : [S.n.], 2017, p. 1-1, no. 242
مصطلحات موضوعية: Diabetes, gestational, Transcription Factor 7-Like 2 protein, Metabolic syndrome X, info:eu-repo/classification/udc/618.3-06:616.379-008.64
الوصف: Objective: To determine the association of genetic variants of TCF7L2 gene and metabolic parameters(glycaemia, insulin, adypocitokines, incretins) in women with previously diagnosed GDM. Methods: We examined 135 women with previously(15-43 years ago) diagnosed GDM. BMI, metabolic syndrome (MS) was evaluated. Fasting plasma glucose (FPG) was examined for women with DM. OGTT was performed for carbohydrate metabolism testing for the rest. Biochemical data (glycaemia,fasting plasma insulin,adiponectine,leptine,GIP,GLP-1) were tested, HOMA-IR was calculated. TCF7L2 SNP common variants(rs7901695, rs7903146, rs7895340, rs11196205, rs12255372) were set. The results were considered statistically significant at p0.05. Results: The mean age was 53,42±8,29years, BMI–30,96±7,66kg/m². Age differed in separate carbohydrate dysmetabolism groups(p = 0.006). Carbohydrate dysmetabolism was set for 57%: 9(6.7%) were diagnosed with IFG, 13(9.6%) with IGT, 55(40.7%) with DM. Only TCF7L2 rs7903146 CT allele more frequently was observed(40(69%)vs.18(31%)) in women with impaired carbohydrate metabolism(p=0.025). A multivariate logistic regression analysis showed that OR of developing DM in women with TCF7L2 rs7903146 CT allele is 2.85(CI 1.17to6.93). We did not find any statistically significant differences in biochemical testings (glycaemia,insulin,adpocytokines,incretins) in separate alleles of TCF7L2 SNP (p0.05). No statistical significance was found in separate TCF7L2 alleles and MS frequency. Women with DM were observed to have higher insulin resistance(HOMA-IR 7.61±6.3) compared to women with normal glucose tolerance 2.61±1.14(p0.001), but no statistical significance was observed in separate TCF7L2 SNP alleles. Conclusions: TCF7L2 rs7903146 CT allele was seen half a more frequently in women with impaired carbohydrate metabolism. No statistical significant difference was found in separete alleles of TCF7L2 and b
