التفاصيل البيبلوغرافية
| العنوان: |
HTLV-1 bZIP factor impairs cell-mediated immunity by suppressing production of Th1 cytokines. |
| المؤلفون: |
Sugata, Kenji, Satou, Yorifumi, Yasunaga, Jun-Ichirou, Hara, Hideki, Ohshima, Kouichi, Utsunomiya, Atae, Mitsuyama, Masao, Matsuoka, Masao |
| المساهمون: |
松岡, 雅雄, 40362404, 10117260, 10244138 |
| بيانات النشر: |
The American Society of Hematology |
| سنة النشر: |
2012 |
| المجموعة: |
Kyoto University Research Information Repository (KURENAI) / 京都大学学術情報リポジトリ |
| الوصف: |
Adult T-cell leukemia (ATL) patients and human T-cell leukemia virus-1 (HTLV-1) infected individuals succumb to opportunistic infections. Cell mediated immunity is impaired, yet the mechanism of this impairment has remained elusive. The HTLV-1 basic leucine zipper factor (HBZ) gene is encoded in the minus strand of the viral DNA and is constitutively expressed in infected cells and ATL cells. To test the hypothesis that HBZ contributes to HTLV-1-associated immunodeficiency, we challenged transgenic mice that express the HBZ gene in CD4 T cells (HBZ-Tg mice) with herpes simplex virus type 2 or Listeria monocytogenes, and evaluated cellular immunity to these pathogens. HBZ-Tg mice were more vulnerable to both infections than non-Tg mice. The acquired immune response phase was specifically suppressed, indicating that cellular immunity was impaired in HBZ-Tg mice. In particular, production of IFN-γ by CD4 T cells was suppressed in HBZ-Tg mice. HBZ suppressed transcription from the IFN-γ gene promoter in a CD4 T cell-intrinsic manner by inhibiting nuclear factor of activated T cells and the activator protein 1 signaling pathway. This study shows that HBZ inhibits CD4 T-cell responses by directly interfering with the host cell-signaling pathway, resulting in impaired cell-mediated immunity in vivo. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
0006-4971 |
| العلاقة: |
http://bloodjournal.hematologylibrary.org/content/119/2/434.abstractTest; Sugata K, Satou Y, Yasunaga J, Hara H, Ohshima K, Utsunomiya A, Mitsuyama M, Matsuoka M. HTLV-1 bZIP factor impairs cell-mediated immunity by suppressing production of Th1 cytokines. Blood. 2012 Jan 12;119(2):434-44. Epub 2011 Nov 28.; http://hdl.handle.net/2433/152416Test; Blood; 119; 434; 444 |
| الإتاحة: |
http://hdl.handle.net/2433/152416Test |
| حقوق: |
© 2012 by The American Society of Hematology |
| رقم الانضمام: |
edsbas.95042648 |
| قاعدة البيانات: |
BASE |
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