التفاصيل البيبلوغرافية
| العنوان: |
Tumour hypoxia promotes melanoma growth and metastasis via High Mobility Group Box-1 and M2-like macrophages |
| المؤلفون: |
Huber, Roman, Meier, Barbara, Otsuka, Atsushi, Fenini, Gabriele, Satoh, Takashi, Gehrke, Samuel, Widmer, Daniel, Levesque, Mitchell P., Mangana, Joanna, Kerl, Katrin, Gebhardt, Christoffer, Fujii, Hiroko, Nakashima, Chisa, Nonomura, Yumi, Kabashima, Kenji, Dummer, Reinhard, Contassot, Emmanuel, French, Lars E. |
| المساهمون: |
大塚, 篤司, 中嶋, 千紗, 野々村, 優美, 椛島, 健治, 00362484 |
| بيانات النشر: |
Springer Science and Business Media LLC |
| سنة النشر: |
2016 |
| المجموعة: |
Kyoto University Research Information Repository (KURENAI) / 京都大学学術情報リポジトリ |
| الوصف: |
Hypoxia is a hallmark of cancer that is strongly associated with invasion, metastasis, resistance to therapy and poor clinical outcome. Tumour hypoxia affects immune responses and promotes the accumulation of macrophages in the tumour microenvironment. However, the signals linking tumour hypoxia to tumour-associated macrophage recruitment and tumour promotion are incompletely understood. Here we show that the damage-associated molecular pattern High-Mobility Group Box 1 protein (HMGB1) is released by melanoma tumour cells as a consequence of hypoxia and promotes M2-like tumour-associated macrophage accumulation and an IL-10 rich milieu within the tumour. Furthermore, we demonstrate that HMGB1 drives IL-10 production in M2-like macrophages by selectively signalling through the Receptor for Advanced Glycation End products (RAGE). Finally, we show that HMGB1 has an important role in murine B16 melanoma growth and metastasis, whereas in humans its serum concentration is significantly increased in metastatic melanoma. Collectively, our findings identify a mechanism by which hypoxia affects tumour growth and metastasis in melanoma and depict HMGB1 as a potential therapeutic target. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
2045-2322 |
| العلاقة: |
http://hdl.handle.net/2433/245563Test; Scientific reports; 29914 |
| الإتاحة: |
http://hdl.handle.net/2433/245563Test |
| حقوق: |
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.8DCE4D90 |
| قاعدة البيانات: |
BASE |
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