دورية أكاديمية
Magnitude of slowing gastric emptying by glucagon‐like peptide‐1 receptor agonists determines the amelioration of postprandial glucose excursion in Japanese patients with type 2 diabetes
| العنوان: | Magnitude of slowing gastric emptying by glucagon‐like peptide‐1 receptor agonists determines the amelioration of postprandial glucose excursion in Japanese patients with type 2 diabetes |
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| المؤلفون: | Suganuma, Yumi, Shimizu, Tatsunori, Sato, Takehiro, Morii, Tsukasa, Fujita, Hiroki, Harada Sassa, Mariko, Yamada, Yuichiro |
| المساهمون: | 菅沼, 由美, 清水, 辰徳, 佐藤, 雄大, 森井, 宰, 藤田, 浩樹, 佐々, 真理子, 山田, 祐一郎 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2020 |
| المجموعة: | Kyoto University Research Information Repository (KURENAI) / 京都大学学術情報リポジトリ |
| مصطلحات موضوعية: | Continuous 13C breath test, Gastric emptying, Glucagon‐like peptide‐1 receptor agonists |
| الوصف: | Aims/Introduction: Pharmacological levels of glucagon‐like peptide‐1 (GLP‐1) can decelerate gastric emptying (GE) and reduce postprandial glucose levels. Most previous studies have used liquid meals to evaluate GE. We evaluated the effects of GLP‐1 receptor agonists (GLP‐1 RAs) on GE and postprandial glucose excursion in Japanese type 2 diabetes mellitus patients using a combination of solid and liquid meals. Materials and Methods: In this single‐center, prospective, open‐label study, nine healthy individuals and 17 patients with type 2 diabetes mellitus consumed a 460‐kcal combination of a solid and liquid meal labeled with 13C‐acetic acid. GE was measured from t = 0 to 150 min in a continuous 13C breath test. Eight participants with type 2 diabetes mellitus were administered GLP‐1 RAs, and we examined the relationship between GE and blood glucose excursion. Results: There were no differences in the average GE coefficient (GEC) and lag time between the healthy and type 2 diabetes mellitus groups. However, the type 2 diabetes mellitus group showed larger GEC variations (P < 0.05). The coefficient of variation of R‐R intervals was a significant predictor of GEC in type 2 diabetes mellitus patients (P < 0.01). The short‐acting GLP‐1 RA reduced the GEC at 1 month (P = 0.012), whereas the long‐acting GLP‐1 RA did not significantly change the GEC after treatment. A positive relationship was observed between postprandial glucose excursion from T0 min to T60 min and the GEC (r2 = 0.75; P < 0.01). Conclusions: The reduction in GE rate by the administration of GLP‐1 RAs can predict the improvement in postprandial glucose excursion in type 2 diabetes mellitus patients. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2040-1116 2040-1124 |
| العلاقة: | http://hdl.handle.net/2433/250109Test; Journal of Diabetes Investigation; 11; 389; 399 |
| الإتاحة: | http://hdl.handle.net/2433/250109Test |
| حقوق: | © 2019 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
| رقم الانضمام: | edsbas.36F67256 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20401116 20401124 |
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