التفاصيل البيبلوغرافية
| العنوان: |
Ca(2+)-dependent binding of calcium-binding protein 1 to presynaptic group III metabotropic glutamate receptors and blockage by phosphorylation of the receptors. |
| المؤلفون: |
Nakajima, Yoshiaki |
| المساهمون: |
中嶋, 善明 |
| بيانات النشر: |
Elsevier Inc. |
| سنة النشر: |
2011 |
| المجموعة: |
Kyoto University Research Information Repository (KURENAI) / 京都大学学術情報リポジトリ |
| مصطلحات موضوعية: |
mGluR, Calcium-binding protein 1, Calmodulin, Presynaptic, Calcium channel, Glutamate receptor |
| الوصف: |
Presynaptic group III metabotropic glutamate receptors (mGluRs) and Ca(2+) channels are the main neuronal activity-dependent regulators of synaptic vesicle release, and they use common molecules in their signaling cascades. Among these, calmodulin (CaM) and the related EF-hand Ca(2+)-binding proteins are of particular importance as sensors of presynaptic Ca(2+), and a multiple of them are indeed utilized in the signaling of Ca(2+) channels. However, despite its conserved structure, CaM is the only known EF-hand Ca(2+)-binding protein for signaling by presynaptic group III mGluRs. Because the mGluRs and Ca(2+) channels reciprocally regulate each other and functionally converge on the regulation of synaptic vesicle release, the mGluRs would be expected to utilize more EF-hand Ca(2+)-binding proteins in their signaling. Here I show that calcium-binding protein 1 (CaBP1) bound to presynaptic group III mGluRs competitively with CaM in a Ca(2+)-dependent manner and that this binding was blocked by protein kinase C (PKC)-mediated phosphorylation of these receptors. As previously shown for CaM, these results indicate the importance of CaBP1 in signal cross talk at presynaptic group III mGluRs, which includes many molecules such as cAMP, Ca(2+), PKC, G protein, and Munc18-1. However, because the functional diversity of EF-hand calcium-binding proteins is extraordinary, as exemplified by the regulation of Ca(2+) channels, CaBP1 would provide a distinct way by which presynaptic group III mGluRs fine-tune synaptic transmission. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
0006-291X |
| العلاقة: |
http://hdl.handle.net/2433/147235Test; AA00564395; Biochemical and biophysical research communications; 412; 602; 605 |
| الإتاحة: |
http://hdl.handle.net/2433/147235Test |
| حقوق: |
© 2011 Elsevier Inc. ; This is not the published version. Please cite only the published version. ; この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
| رقم الانضمام: |
edsbas.3008B040 |
| قاعدة البيانات: |
BASE |
